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X Demographics
Mendeley readers
Attention Score in Context
| Title |
N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis
|
|---|---|
| Published in |
Journal of Clinical Epidemiology, April 2016
|
| DOI | 10.1016/j.jclinepi.2016.03.026 |
| Pubmed ID | |
| Authors |
Salima Punja, Dongying Xu, Christopher H. Schmid, Lisa Hartling, Liana Urichuk, Catherine Jane Nikles, Sunita Vohra |
| Abstract |
To evaluate how data from n-of-1 trials may be used in systematic reviews and meta-analyses by examining the effects of amphetamine and methylphenidate for attention-deficit/hyperactivity disorder (ADHD). Electronic search of MEDLINE, EMBASE, and PsychINFO for English language articles published from 1950-2013. N-of-1 trials of pediatric participants with ADHD that assessed either amphetamine or methylphenidate versus placebo were included. The primary outcome was improvement of core symptoms of ADHD, which was assessed by multiple rating scales. Studies with obtainable individual participant data were included in the meta-analysis. Weighted mean differences were computed using a random effects-model. Nine studies were included in the amphetamine-placebo comparison, and ten in the methylphenidate-placebo comparison. Meta-analyses were consistently in favour of amphetamine in 10 out of 11 ADHD symptom domains and methylphenidate in 7 out of 12 symptom domains. A high degree of heterogeneity across participant treatment response was observed. Meta-analysis of n-of-1 trials suggests that amphetamine and methylphenidate are effective treatments for pediatric ADHD. Synthesizing n-of-1 trials enables assessment of individual responses to treatment as well as aggregate summaries across individuals and studies. It offers a promising general approach with applications across diverse treatments and disorders. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 29% |
| Canada | 2 | 29% |
| United Kingdom | 1 | 14% |
| United States | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| United States | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 101 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 17% |
| Student > Ph. D. Student | 12 | 12% |
| Student > Bachelor | 11 | 11% |
| Student > Doctoral Student | 9 | 9% |
| Other | 8 | 8% |
| Other | 26 | 25% |
| Unknown | 20 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 26% |
| Psychology | 14 | 13% |
| Social Sciences | 5 | 5% |
| Neuroscience | 5 | 5% |
| Computer Science | 3 | 3% |
| Other | 17 | 16% |
| Unknown | 33 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2021.
All research outputs
#3,184,130
of 25,654,806 outputs
Outputs from Journal of Clinical Epidemiology
#1,210
of 4,812 outputs
Outputs of similar age
#48,017
of 314,098 outputs
Outputs of similar age from Journal of Clinical Epidemiology
#13
of 54 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,812 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,098 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.