Title |
Insights into Myeloid-Derived Suppressor Cells in Inflammatory Diseases
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Published in |
Archivum Immunologiae et Therapiae Experimentalis, May 2015
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DOI | 10.1007/s00005-015-0342-1 |
Pubmed ID | |
Authors |
Yewon Kwak, Hye-Eun Kim, Sung Gyoo Park |
Abstract |
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells involved in immune regulation. This population subdivides into granulocytic MDSCs and monocytic MDSCs, which regulate immune responses via the production of various molecules including reactive oxygen species, nitric oxide, arginase-1, interleukin-10, and transforming growth factor-β. Most studies of MDSCs focused on their role in tumors. MDSCs protect tumor cells from immune responses, and thus the frequency of MDSCs associates with poor prognosis. Many recent studies reported an important role for MDSCs in inflammatory diseases via the regulation of immune cells. In addition, the utilization of MDSCs by infectious pathogens suggests an immune evasion mechanism. Thus, MDSCs are important immune regulators in inflammatory diseases, as well as in tumors. This review focuses on the role of MDSCs in the regulation of inflammation in non-tumor settings. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Unknown | 28 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 21% |
Researcher | 5 | 17% |
Student > Bachelor | 3 | 10% |
Professor > Associate Professor | 2 | 7% |
Student > Master | 2 | 7% |
Other | 4 | 14% |
Unknown | 7 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 21% |
Immunology and Microbiology | 5 | 17% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Agricultural and Biological Sciences | 2 | 7% |
Unspecified | 1 | 3% |
Other | 2 | 7% |
Unknown | 10 | 34% |