| Title |
A genomewide scan of male sexual orientation
|
|---|---|
| Published in |
Human Genetics, January 2005
|
| DOI | 10.1007/s00439-004-1241-4 |
| Pubmed ID | |
| Authors |
Brian S. Mustanski, Michael G. DuPree, Caroline M. Nievergelt, Sven Bocklandt, Nicholas J. Schork, Dean H. Hamer |
| Abstract |
This is the first report of a full genome scan of sexual orientation in men. A sample of 456 individuals from 146 families with two or more gay brothers was genotyped with 403 microsatellite markers at 10-cM intervals. Given that previously reported evidence of maternal loading of transmission of sexual orientation could indicate epigenetic factors acting on autosomal genes, maximum likelihood estimations (mlod) scores were calculated separated for maternal, paternal, and combined transmission. The highest mlod score was 3.45 at a position near D7S798 in 7q36 with approximately equivalent maternal and paternal contributions. The second highest mlod score of 1.96 was located near D8S505 in 8p12, again with equal maternal and paternal contributions. A maternal origin effect was found near marker D10S217 in 10q26, with a mlod score of 1.81 for maternal meioses and no paternal contribution. We did not find linkage to Xq28 in the full sample, but given the previously reported evidence of linkage in this region, we conducted supplemental analyses to clarify these findings. First, we re-analyzed our previously reported data and found a mlod of 6.47. We then re-analyzed our current data, after limiting the sample to those families previously reported, and found a mlod of 1.99. These Xq28 findings are discussed in detail. The results of this first genome screen for normal variation in the behavioral trait of sexual orientation in males should encourage efforts to replicate these findings in new samples with denser linkage maps in the suggested regions. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Dominican Republic | 1 | 9% |
| Canada | 1 | 9% |
| Chile | 1 | 9% |
| Argentina | 1 | 9% |
| Colombia | 1 | 9% |
| Poland | 1 | 9% |
| Unknown | 5 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Scientists | 2 | 18% |
Mendeley readers
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 2% |
| United States | 3 | 1% |
| China | 2 | <1% |
| France | 1 | <1% |
| Mexico | 1 | <1% |
| Sweden | 1 | <1% |
| Colombia | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 209 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 48 | 22% |
| Student > Ph. D. Student | 41 | 18% |
| Student > Master | 28 | 13% |
| Researcher | 25 | 11% |
| Professor | 16 | 7% |
| Other | 44 | 20% |
| Unknown | 21 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 58 | 26% |
| Psychology | 46 | 21% |
| Medicine and Dentistry | 27 | 12% |
| Social Sciences | 19 | 9% |
| Biochemistry, Genetics and Molecular Biology | 15 | 7% |
| Other | 29 | 13% |
| Unknown | 29 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 127. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2023.
All research outputs
#331,017
of 25,559,053 outputs
Outputs from Human Genetics
#17
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Outputs of similar age
#503
of 153,894 outputs
Outputs of similar age from Human Genetics
#1
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