| Title |
Extreme skewing of X chromosome inactivation in mothers of homosexual men
|
|---|---|
| Published in |
Human Genetics, December 2005
|
| DOI | 10.1007/s00439-005-0119-4 |
| Pubmed ID | |
| Authors |
Sven Bocklandt, Steve Horvath, Eric Vilain, Dean H. Hamer |
| Abstract |
Human sexual preference is a sexually dimorphic trait with a substantial genetic component. Linkage of male sexual orientation to markers on the X chromosome has been reported in some families. Here, we measured X chromosome inactivation ratios in 97 mothers of homosexual men and 103 age-matched control women without gay sons. The number of women with extreme skewing of X-inactivation was significantly higher in mothers of gay men (13/97=13%) compared to controls (4/103=4%) and increased in mothers with two or more gay sons (10/44=23%). Our findings support a role for the X chromosome in regulating sexual orientation in a subgroup of gay men. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Poland | 1 | 11% |
| Germany | 1 | 11% |
| Tunisia | 1 | 11% |
| Unknown | 6 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 89% |
| Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| United Kingdom | 2 | 1% |
| Italy | 1 | <1% |
| Sweden | 1 | <1% |
| France | 1 | <1% |
| India | 1 | <1% |
| Belgium | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 131 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 22% |
| Student > Bachelor | 23 | 16% |
| Student > Master | 19 | 13% |
| Researcher | 15 | 10% |
| Professor > Associate Professor | 13 | 9% |
| Other | 29 | 20% |
| Unknown | 12 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 50 | 35% |
| Psychology | 24 | 17% |
| Medicine and Dentistry | 16 | 11% |
| Biochemistry, Genetics and Molecular Biology | 14 | 10% |
| Neuroscience | 10 | 7% |
| Other | 15 | 10% |
| Unknown | 14 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2022.
All research outputs
#1,701,924
of 24,282,284 outputs
Outputs from Human Genetics
#133
of 3,045 outputs
Outputs of similar age
#4,634
of 159,764 outputs
Outputs of similar age from Human Genetics
#2
of 19 outputs
Altmetric has tracked 24,282,284 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,045 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 159,764 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.