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Early-Life Intranasal Colonization with Nontypeable Haemophilus influenzae Exacerbates Juvenile Airway Disease in Mice

Overview of attention for article published in Infection and Immunity, June 2016
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  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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Citations

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23 Mendeley
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Title
Early-Life Intranasal Colonization with Nontypeable Haemophilus influenzae Exacerbates Juvenile Airway Disease in Mice
Published in
Infection and Immunity, June 2016
DOI 10.1128/iai.01539-15
Pubmed ID
Authors

Jessica R. McCann, Stanley N. Mason, Richard L. Auten, Joseph W. St. Geme, Patrick C. Seed

Abstract

Accumulating evidence suggests a connection between asthma development and colonization with nontypeable Haemophilus influenzae (NTHi). Specifically, nasopharyngeal colonization of human infants with NTHi within 4 weeks of birth is associated with an increased risk of asthma development later in childhood. Monocytes derived from these infants have aberrant inflammatory responses to common upper respiratory bacterial antigens when compared to cells derived from infants who were not colonized and do not go on to develop asthma symptoms in childhood. In this study, we hypothesized that early life colonization with NTHi promotes immune system reprogramming and the development of atypical inflammatory responses. To address this hypothesis in a highly controlled model, we tested whether colonization of mice with NTHi on day of life 3 induced or exacerbated juvenile airways disease using an ovalbumin (OVA) allergic model of asthma. We found that animals that were colonized on day of life 3 and subjected to induction of allergy had exacerbated airways disease as juveniles, defined as increased cellular infiltration into the lung, increased inflammatory cytokines IL5 and IL13 in the lung lavage fluid, decreased regulatory T cell-associated FOXP3 gene expression, and increased mucus production. We also found that colonization with NTHi amplified airway resistance in response to increasing doses of a bronchoconstrictor following OVA immunization and challenge. Together, the murine model provides evidence for early life immune programming that precedes the development of juvenile airways disease and corroborates observations in human children.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 17%
Student > Postgraduate 4 17%
Professor > Associate Professor 3 13%
Researcher 2 9%
Student > Bachelor 2 9%
Other 2 9%
Unknown 6 26%
Readers by discipline Count As %
Immunology and Microbiology 6 26%
Medicine and Dentistry 5 22%
Biochemistry, Genetics and Molecular Biology 4 17%
Agricultural and Biological Sciences 1 4%
Nursing and Health Professions 1 4%
Other 0 0%
Unknown 6 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2016.
All research outputs
#6,746,497
of 25,377,790 outputs
Outputs from Infection and Immunity
#4,145
of 13,522 outputs
Outputs of similar age
#104,069
of 368,655 outputs
Outputs of similar age from Infection and Immunity
#12
of 56 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 13,522 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 368,655 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.