Title |
Comparing the Standard and Electronic Versions of the Alzheimer’s Disease Assessment Scale — Cognitive Subscale: A Validation Study
|
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Published in |
The Journal of Prevention of Alzheimer's Disease, June 2019
|
DOI | 10.14283/jpad.2019.27 |
Pubmed ID | |
Authors |
Todd M. Solomon, J. M. Barbone, H. T. Feaster, D. S. Miller, G. B. deBros, C. A. Murphy, D. Michalczuk |
Abstract |
The Alzheimer's Disease Assessment Scale (ADAS-Cog) has become the de facto gold-standard for assessing the efficacy of putative anti-dementia treatments. There has been an increasing interest in providing greater standardization, automation, and administration consistency to the scale. Recently, electronic versions of the ADAS-Cog (eADAS-Cog) have been utilized in clinical trials and demonstrated significant reductions in frequency of rater error as compared to paper. In order to establish validity of the electronic version (eADAS-Cog), 20 subjects who had received a diagnosis of probable Alzheimer's disease (AD) at a private US Memory Clinic completed a single-center, randomized, counterbalanced, prospective trial comparing a version of the eADAS-Cog to the standard paper scale. Interclass Correlation Coefficient on total scores and Kappa analysis on domain scores yielded high agreement (0.88 - 0.99). Effects of order and mode of administration on ADAS-Cog total scores did not demonstrate a significant main effect. Overall, this study establishes adequate concurrent validity between the ADAS-Cog and eADAS-Cog among an adult population with diagnosed AD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 4 | 50% |
Australia | 1 | 13% |
United States | 1 | 13% |
Canada | 1 | 13% |
Unknown | 1 | 13% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 50% |
Scientists | 3 | 38% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 20% |
Student > Bachelor | 4 | 20% |
Student > Doctoral Student | 2 | 10% |
Lecturer | 1 | 5% |
Other | 1 | 5% |
Other | 2 | 10% |
Unknown | 6 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 3 | 15% |
Chemical Engineering | 2 | 10% |
Medicine and Dentistry | 2 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Social Sciences | 1 | 5% |
Other | 3 | 15% |
Unknown | 8 | 40% |