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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome-wide association study of intracranial aneurysm identifies three new risk loci
|
|---|---|
| Published in |
Nature Genetics, April 2010
|
| DOI | 10.1038/ng.563 |
| Pubmed ID | |
| Authors |
Katsuhito Yasuno, Kaya Bilguvar, Philippe Bijlenga, Siew-Kee Low, Boris Krischek, Georg Auburger, Matthias Simon, Dietmar Krex, Zulfikar Arlier, Nikhil Nayak, Ynte M Ruigrok, Mika Niemelä, Atsushi Tajima, Mikael von und zu Fraunberg, Tamás Dóczi, Florentina Wirjatijasa, Akira Hata, Jordi Blasco, Agi Oszvald, Hidetoshi Kasuya, Gulam Zilani, Beate Schoch, Pankaj Singh, Carsten Stüer, Roelof Risselada, Jürgen Beck, Teresa Sola, Filomena Ricciardi, Arpo Aromaa, Thomas Illig, Stefan Schreiber, Cornelia M van Duijn, Leonard H van den Berg, Claire Perret, Carole Proust, Constantin Roder, Ali K Ozturk, Emília Gaál, Daniela Berg, Christof Geisen, Christoph M Friedrich, Paul Summers, Alejandro F Frangi, Matthew W State, H Erich Wichmann, Monique M B Breteler, Cisca Wijmenga, Shrikant Mane, Leena Peltonen, Vivas Elio, Miriam C J M Sturkenboom, Patricia Lawford, James Byrne, Juan Macho, Erol I Sandalcioglu, Bernhard Meyer, Andreas Raabe, Helmuth Steinmetz, Daniel Rüfenacht, Juha E Jääskeläinen, Juha Hernesniemi, Gabriel J E Rinkel, Hitoshi Zembutsu, Ituro Inoue, Aarno Palotie, François Cambien, Yusuke Nakamura, Richard P Lifton, Murat Günel |
| Abstract |
Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall; their hemorrhage commonly results in severe neurologic impairment and death. We report a second genome-wide association study with discovery and replication cohorts from Europe and Japan comprising 5,891 cases and 14,181 controls with approximately 832,000 genotyped and imputed SNPs across discovery cohorts. We identified three new loci showing strong evidence for association with intracranial aneurysms in the combined dataset, including intervals near RBBP8 on 18q11.2 (odds ratio (OR) = 1.22, P = 1.1 x 10(-12)), STARD13-KL on 13q13.1 (OR = 1.20, P = 2.5 x 10(-9)) and a gene-rich region on 10q24.32 (OR = 1.29, P = 1.2 x 10(-9)). We also confirmed prior associations near SOX17 (8q11.23-q12.1; OR = 1.28, P = 1.3 x 10(-12)) and CDKN2A-CDKN2B (9p21.3; OR = 1.31, P = 1.5 x 10(-22)). It is noteworthy that several putative risk genes play a role in cell-cycle progression, potentially affecting the proliferation and senescence of progenitor-cell populations that are responsible for vascular formation and repair. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 2% |
| Denmark | 2 | 1% |
| Germany | 1 | <1% |
| Australia | 1 | <1% |
| Finland | 1 | <1% |
| Colombia | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 166 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 43 | 24% |
| Student > Ph. D. Student | 32 | 18% |
| Professor | 14 | 8% |
| Other | 13 | 7% |
| Professor > Associate Professor | 12 | 7% |
| Other | 31 | 17% |
| Unknown | 33 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 53 | 30% |
| Agricultural and Biological Sciences | 39 | 22% |
| Biochemistry, Genetics and Molecular Biology | 28 | 16% |
| Engineering | 6 | 3% |
| Neuroscience | 5 | 3% |
| Other | 8 | 4% |
| Unknown | 39 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2014.
All research outputs
#1,422,129
of 25,837,817 outputs
Outputs from Nature Genetics
#2,130
of 7,639 outputs
Outputs of similar age
#4,627
of 106,366 outputs
Outputs of similar age from Nature Genetics
#5
of 47 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.7. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 106,366 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.