Title |
Unusual high dose of tacrolimus in liver transplant patient, a case report
|
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Published in |
International Journal of Clinical Pharmacy, March 2012
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DOI | 10.1007/s11096-012-9622-6 |
Pubmed ID | |
Authors |
Alessio Provenzani, Monica Notarbartolo, Manuela Labbozzetta, Paola Poma, Adele D’Antoni, Piera Polidori, Giovanni Vizzini, Natale D’Alessandro |
Abstract |
We describe the case of a liver transplant patient who had great difficulty in reaching the desired trough blood levels despite the use of high dose tacrolimus. The patient was homozygous for the CYP3A5*3 allele. However, the respective donor carried the wild-type CYP3A5*1/*1 genotype. Regarding ABCB1 SNPs at exon 21 and 26, the patient showed the 2677GT and 3435CC genotypes. For the corresponding donor we observed the 2677GG and 3435CC wild-type genotypes. One, two and three weeks after transplantation the patient received daily 0.219, 0.287 and 0.273 mg/kg of tacrolimus, respectively. However, the corresponding tacrolimus trough blood levels were of 4.6, 5.6 and 6.1 ng/mL. The tacrolimus target level of 10.4 ng/mL was finally reached after 1 month of therapy. During the entire period of observation the kidney showed no sign of damage. No other signs of toxicity were reported except for the occurrence of an isolated systolic hypertension. |
X Demographics
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Spain | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Student > Doctoral Student | 2 | 12% |
Student > Ph. D. Student | 2 | 12% |
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Unspecified | 1 | 6% |
Other | 0 | 0% |
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