Title |
The Frequency of Malaria Is Similar among Women Receiving either Lopinavir/Ritonavir or Nevirapine-based Antiretroviral Treatment
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Published in |
PLOS ONE, April 2012
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DOI | 10.1371/journal.pone.0034399 |
Pubmed ID | |
Authors |
Tina S. Skinner-Adams, Alice S. Butterworth, Kimberly A. Porter, Ronald D'Amico, Fred Sawe, Doug Shaffer, Abraham Siika, Mina C. Hosseinipour, Elizabeth Stringer, Judith S. Currier, Tsungai Chipato, Robert Salata, Shahin Lockman, Joseph J. Eron, Steven R. Meshnick, James S. McCarthy |
Abstract |
HIV protease inhibitors (PIs) show antimalarial activity in vitro and in animals. Whether this translates into a clinical benefit in HIV-infected patients residing in malaria-endemic regions is unknown. We studied the incidence of malaria, as defined by blood smear positivity or a positive Plasmodium falciparum histidine-rich protein 2 antigen test, among 444 HIV-infected women initiating antiretroviral treatment (ART) in the OCTANE trial (A5208; ClinicalTrials.gov: NCT00089505). Participants were randomized to treatment with PI-containing vs. PI-sparing ART, and were followed prospectively for ≥48 weeks; 73% also received cotrimoxazole prophylaxis. PI-containing treatment was not associated with protection against malaria in this study population. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Indonesia | 1 | 3% |
United Kingdom | 1 | 3% |
Portugal | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 31 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 20% |
Professor | 4 | 11% |
Researcher | 4 | 11% |
Student > Doctoral Student | 4 | 11% |
Lecturer | 2 | 6% |
Other | 10 | 29% |
Unknown | 4 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 46% |
Computer Science | 3 | 9% |
Business, Management and Accounting | 2 | 6% |
Agricultural and Biological Sciences | 2 | 6% |
Social Sciences | 2 | 6% |
Other | 4 | 11% |
Unknown | 6 | 17% |