| Title |
Quantification of particle-induced inflammatory stress response: a novel approach for toxicity testing of earth materials
|
|---|---|
| Published in |
Geochemical Transactions, April 2012
|
| DOI | 10.1186/1467-4866-13-4 |
| Pubmed ID | |
| Authors |
Andrea D Harrington, Stella E Tsirka, Martin AA Schoonen |
| Abstract |
Reactive oxygen species (ROS) are vital regulators of many cellular functions in the body. The intracellular ROS concentration is highly regulated by a balance between pro-oxidants and anti-oxidants. A chronic excess of pro-oxidants leads to elevated ROS concentrations and inflammation, possibly initiating or enhancing disease onset. Mineral-induced generation of ROS, the role of minerals in upregulating cellular ROS, and their role in the development of several occupational diseases are now widely recognized. However, there is no standard protocol to determine changes in ROS production in cells after exposure to mineral dust or earth materials in general. In this study, a new method for determining the degree of cellular toxicity (i.e., cytotoxicity) of particles is described that will help bridge the gap in knowledge. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 17% |
| Student > Doctoral Student | 3 | 13% |
| Professor | 3 | 13% |
| Student > Ph. D. Student | 3 | 13% |
| Student > Postgraduate | 2 | 8% |
| Other | 6 | 25% |
| Unknown | 3 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 13% |
| Engineering | 3 | 13% |
| Medicine and Dentistry | 3 | 13% |
| Earth and Planetary Sciences | 3 | 13% |
| Chemical Engineering | 2 | 8% |
| Other | 5 | 21% |
| Unknown | 5 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2012.
All research outputs
#18,305,445
of 22,664,267 outputs
Outputs from Geochemical Transactions
#59
of 80 outputs
Outputs of similar age
#124,869
of 161,880 outputs
Outputs of similar age from Geochemical Transactions
#1
of 1 outputs
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So far Altmetric has tracked 80 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
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