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Phenotype and Polyp Landscape in Serrated Polyposis Syndrome

Overview of attention for article published in The American Journal of Surgical Pathology, June 2012
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Title
Phenotype and Polyp Landscape in Serrated Polyposis Syndrome
Published in
The American Journal of Surgical Pathology, June 2012
DOI 10.1097/pas.0b013e31824e133f
Pubmed ID
Authors

Christophe Rosty, Daniel D. Buchanan, Michael D. Walsh, Sally-Ann Pearson, Erika Pavluk, Rhiannon J. Walters, Mark Clendenning, Kevin J. Spring, Mark A. Jenkins, Aung K. Win, John L. Hopper, Kevin Sweet, Wendy L. Frankel, Melyssa Aronson, Steve Gallinger, Jack Goldblatt, Sonja Woodall, Julie Arnold, Neal I. Walker, Jeremy R. Jass, Susan Parry, Joanne P. Young

Abstract

Serrated polyposis syndrome (SPS), also known as hyperplastic polyposis, is a syndrome of unknown genetic basis defined by the occurrence of multiple serrated polyps in the large intestine and associated with an increased risk of colorectal cancer (CRC). There are a variety of SPS presentations, which may encompass a continuum of phenotypes modified by environmental and genetic factors. To explore the phenotype of SPS, we recorded the histologic and molecular characteristics of multiple colorectal polyps in patients with SPS recruited between 2000 and 2010 from genetics clinics in Australia, New Zealand, Canada, and the United States. Three specialist gastrointestinal pathologists reviewed the polyps, which they classified into conventional adenomas or serrated polyps, with various subtypes, according to the current World Health Organization criteria. Mutations in BRAF and KRAS and mismatch repair protein expression were determined in a subset of polyps. A total of 100 patients were selected for the study, of whom 58 were female and 42 were male. The total polyp count per patient ranged from 6 to 150 (median 30). The vast majority of patients (89%) had polyposis affecting the entire large intestine. From this cohort, 406 polyps were reviewed. Most of the polyps (83%) were serrated polyps: microvesicular hyperplastic polyps (HP) (n=156), goblet cell HP (n=25), sessile serrated adenoma/polyps (SSA/P) (n=110), SSA/P with cytologic dysplasia (n=28), and traditional serrated adenomas (n=18). A further 69 polyps were conventional adenomas. BRAF mutation was mainly detected in SSA/P with dysplasia (95%), SSA/P (85%), microvesicular HP (76%), and traditional serrated adenoma (54%), whereas KRAS mutation was present mainly in goblet cell HP (50%) and in tubulovillous adenoma (45%). Four of 6 SSA/Ps with high-grade dysplasia showed loss of MLH1/PMS2 expression. CRC was diagnosed in 39 patients who were more often found to have a conventional adenoma compared with patients without CRC (P=0.003). Patients with SPS referred to genetics clinics had a pancolonic disease with a high polyp burden and a high rate of BRAF mutation. The occurrence of CRC was associated with the presence of conventional adenoma.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 2%
Italy 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 21%
Professor > Associate Professor 9 21%
Other 5 12%
Student > Doctoral Student 3 7%
Student > Postgraduate 3 7%
Other 8 19%
Unknown 6 14%
Readers by discipline Count As %
Medicine and Dentistry 27 63%
Agricultural and Biological Sciences 2 5%
Biochemistry, Genetics and Molecular Biology 1 2%
Social Sciences 1 2%
Sports and Recreations 1 2%
Other 0 0%
Unknown 11 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2012.
All research outputs
#14,599,159
of 25,371,288 outputs
Outputs from The American Journal of Surgical Pathology
#2,174
of 3,522 outputs
Outputs of similar age
#99,799
of 179,218 outputs
Outputs of similar age from The American Journal of Surgical Pathology
#23
of 39 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,522 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,218 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.