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Pyroptotic cell death defends against intracellular pathogens

Overview of attention for article published in Immunological Reviews, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
3 news outlets
twitter
1 X user
wikipedia
11 Wikipedia pages

Citations

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792 Dimensions

Readers on

mendeley
459 Mendeley
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Title
Pyroptotic cell death defends against intracellular pathogens
Published in
Immunological Reviews, April 2015
DOI 10.1111/imr.12287
Pubmed ID
Authors

Ine Jorgensen, Edward A. Miao

Abstract

Inflammatory caspases play a central role in innate immunity by responding to cytosolic signals and initiating a twofold response. First, caspase-1 induces the activation and secretion of the two prominent pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18. Second, either caspase-1 or caspase-11 can trigger a form of lytic, programmed cell death called pyroptosis. Pyroptosis operates to remove the replication niche of intracellular pathogens, making them susceptible to phagocytosis and killing by a secondary phagocyte. However, aberrant, systemic activation of pyroptosis in vivo may contribute to sepsis. Emphasizing the efficiency of inflammasome detection of microbial infections, many pathogens have evolved to avoid or subvert pyroptosis. This review focuses on molecular and morphological characteristics of pyroptosis and the individual inflammasomes and their contribution to defense against infection in mice and humans.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 459 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 <1%
Norway 1 <1%
Brazil 1 <1%
Mexico 1 <1%
China 1 <1%
United States 1 <1%
Unknown 453 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 99 22%
Student > Master 66 14%
Researcher 48 10%
Student > Bachelor 48 10%
Student > Doctoral Student 32 7%
Other 46 10%
Unknown 120 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 88 19%
Immunology and Microbiology 82 18%
Agricultural and Biological Sciences 75 16%
Medicine and Dentistry 35 8%
Neuroscience 10 2%
Other 28 6%
Unknown 141 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2024.
All research outputs
#1,350,582
of 24,417,958 outputs
Outputs from Immunological Reviews
#56
of 2,244 outputs
Outputs of similar age
#15,839
of 241,786 outputs
Outputs of similar age from Immunological Reviews
#1
of 13 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,244 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,786 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.