| Title |
The Nordic SentiMag trial: a comparison of super paramagnetic iron oxide (SPIO) nanoparticles versus Tc99 and patent blue in the detection of sentinel node (SN) in patients with breast cancer and a meta-analysis of earlier studies
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, April 2016
|
| DOI | 10.1007/s10549-016-3809-9 |
| Pubmed ID | |
| Authors |
Andreas Karakatsanis, Peer Michael Christiansen, Lone Fischer, Christina Hedin, Lida Pistioli, Malin Sund, Nils Ryegaard Rasmussen, Hjørdis Jørnsgård, Daniel Tegnelius, Staffan Eriksson, Kosmas Daskalakis, Fredrik Wärnberg, Christos J. Markopoulos, Leif Bergkvist |
| Abstract |
The aim of the study is to compare the efficacy of SPIO as a tracer in sentinel node biopsy (SNB) in breast cancer with Tc and patent blue in a multicentre prospective study and perform a meta-analysis of all published studies. It also aims to follow skin discoloration after SPIO injection and describe when and how it resolves. Totally 206 patients with early breast cancer were recruited. Tc and patent blue were administered in standard fashion. Patients were injected with SPIO (Sienna+) preoperatively. SNB was performed and detection rates were recorded for both methods. Skin discoloration was followed and documented postoperatively. Data extraction and subsequent meta-analysis of all previous studies were also performed. SN detection rates were similar between standard technique succeeded and SPIO both per patient (97.1 vs. 97.6 %, p = 0.76) as well as per node (91.3 vs. 93.3 %, p = 0.34), something which was not affected by the presence of malignancy. Concordance rates were also consistently high (98.0 % per patient and 95.9 % per node). Discoloring was present in 35.5 % of patients postoperatively, almost exclusively in breast conservation. It fades slowly and is still detectable in 8.6 % of patients after 15 months. Meta-analysis depicted similar detection rates (p = 0.71) and concordance rates (p = 0.82) per patient. However, it seems that SPIO is characterized by higher nodal retrieval (p < 0.001). SPIO is an effective method for the detection of SN in patients with breast cancer. It is comparable to the standard technique and seems to simplify logistics. Potential skin discoloration is something of consideration in patients planned for breast conservation. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 99 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 16% |
| Researcher | 14 | 14% |
| Student > Master | 10 | 10% |
| Other | 8 | 8% |
| Student > Ph. D. Student | 7 | 7% |
| Other | 19 | 19% |
| Unknown | 27 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 40% |
| Biochemistry, Genetics and Molecular Biology | 7 | 7% |
| Nursing and Health Professions | 4 | 4% |
| Chemistry | 4 | 4% |
| Engineering | 4 | 4% |
| Other | 10 | 10% |
| Unknown | 32 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2021.
All research outputs
#4,573,121
of 22,865,319 outputs
Outputs from Breast Cancer Research and Treatment
#849
of 4,659 outputs
Outputs of similar age
#71,962
of 299,013 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#15
of 92 outputs
Altmetric has tracked 22,865,319 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,659 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,013 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.