Title |
Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes
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Published in |
BMC Complementary Medicine and Therapies, April 2012
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DOI | 10.1186/1472-6882-12-47 |
Pubmed ID | |
Authors |
Floyd Dukes, Stathis Kanterakis, James Lee, Ralph Pietrofesa, Emily S Andersen, Evguenia Arguiri, Sonia Tyagi, Louise Showe, Yassine Amrani, Melpo Christofidou-Solomidou |
Abstract |
Flaxseed (FS), a nutritional supplement consisting mainly of omega-3 fatty acids and lignan phenolics has potent anti-inflammatory, anti-fibrotic and antioxidant properties. The usefulness of flaxseed as an alternative and complimentary treatment option has been known since ancient times. We have shown that dietary FS supplementation ameliorates oxidative stress and inflammation in experimental models of acute and chronic lung injury in mice resulting from diverse toxicants. The development of lung tissue damage in response to direct or indirect oxidant stress is a complex process, associated with changes in expression levels of a number of genes. We therefore postulated that flaxseed might modulate gene expression of vital signaling pathways, thus interfering with the development of tissue injury. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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South Africa | 1 | 6% |
Unknown | 17 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 17% |
Student > Bachelor | 2 | 11% |
Student > Master | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Student > Doctoral Student | 1 | 6% |
Other | 3 | 17% |
Unknown | 5 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 22% |
Medicine and Dentistry | 3 | 17% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Materials Science | 1 | 6% |
Other | 0 | 0% |
Unknown | 7 | 39% |