| Title |
Effect of DHA supplementation in a very low-calorie ketogenic diet in the treatment of obesity: a randomized clinical trial
|
|---|---|
| Published in |
Endocrine, April 2016
|
| DOI | 10.1007/s12020-016-0964-z |
| Pubmed ID | |
| Authors |
Daniel de Luis, Joan Carles Domingo, Olatz Izaola, Felipe F. Casanueva, Diego Bellido, Ignacio Sajoux |
| Abstract |
A VLCK diet supplemented with DHA, commercially available, was tested against an isocaloric VLCK diet without DHA. The main purpose of this study was to compare the effect of DHA supplementation in classic cardiovascular risk factors, adipokine levels, and inflammation-resolving eicosanoids. A total of obese patients were randomized into two groups: a group supplemented with DHA (n = 14) (PnK-DHA group) versus a group with an isocaloric diet free of supplementation (n = 15) (control group). The follow-up period was 6 months. The average weight loss after 6 months of treatment was 20.36 ± 5.02 kg in control group and 19.74 ± 5.10 kg in PnK-DHA group, without statistical differences between both groups. The VLCK diets induced a significant change in some of the biological parameters, such as insulin, HOMA-IR, triglycerides, LDL cholesterol, C-reactive protein, resistin, TNF alpha, and leptin. Following DHA supplementation, the DHA-derived oxylipins were significantly increased in the intervention group. The ratio of proresolution/proinflammatory lipid markers was increased in plasma of the intervention group over the entire study. Similarly, the mean ratios of AA/EPA and AA/DHA in erythrocyte membranes were dramatically reduced in the PnK-DHA group and the anti-inflammatory fatty acid index (AIFAI) was consistently increased after the DHA treatment (p < 0.05). The present study demonstrated that a very low-calorie ketogenic diet supplemented with DHA was significantly superior in the anti-inflammatory effect, without statistical differences in weight loss and metabolic improvement. |
X Demographics
The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 9 | 29% |
| United Kingdom | 6 | 19% |
| United States | 5 | 16% |
| Australia | 2 | 6% |
| El Salvador | 1 | 3% |
| New Zealand | 1 | 3% |
| Unknown | 7 | 23% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 71% |
| Practitioners (doctors, other healthcare professionals) | 8 | 26% |
| Scientists | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| Unknown | 196 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 33 | 17% |
| Student > Bachelor | 31 | 16% |
| Researcher | 22 | 11% |
| Student > Postgraduate | 11 | 6% |
| Other | 10 | 5% |
| Other | 32 | 16% |
| Unknown | 58 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 23% |
| Nursing and Health Professions | 25 | 13% |
| Biochemistry, Genetics and Molecular Biology | 16 | 8% |
| Agricultural and Biological Sciences | 15 | 8% |
| Sports and Recreations | 4 | 2% |
| Other | 16 | 8% |
| Unknown | 75 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2018.
All research outputs
#1,008,792
of 23,406,603 outputs
Outputs from Endocrine
#42
of 1,734 outputs
Outputs of similar age
#18,693
of 300,369 outputs
Outputs of similar age from Endocrine
#2
of 37 outputs
Altmetric has tracked 23,406,603 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,734 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done particularly well, scoring higher than 97% of its peers.
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