Title |
The stepped wedge trial design: a systematic review
|
---|---|
Published in |
BMC Medical Research Methodology, November 2006
|
DOI | 10.1186/1471-2288-6-54 |
Pubmed ID | |
Authors |
Celia A Brown, Richard J Lilford |
Abstract |
Stepped wedge randomised trial designs involve sequential roll-out of an intervention to participants (individuals or clusters) over a number of time periods. By the end of the study, all participants will have received the intervention, although the order in which participants receive the intervention is determined at random. The design is particularly relevant where it is predicted that the intervention will do more good than harm (making a parallel design, in which certain participants do not receive the intervention unethical) and/or where, for logistical, practical or financial reasons, it is impossible to deliver the intervention simultaneously to all participants. Stepped wedge designs offer a number of opportunities for data analysis, particularly for modelling the effect of time on the effectiveness of an intervention. This paper presents a review of 12 studies (or protocols) that use (or plan to use) a stepped wedge design. One aim of the review is to highlight the potential for the stepped wedge design, given its infrequent use to date. |
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United Kingdom | 10 | 26% |
Canada | 6 | 15% |
Dominican Republic | 1 | 3% |
Norway | 1 | 3% |
Netherlands | 1 | 3% |
Cuba | 1 | 3% |
Unknown | 8 | 21% |
Demographic breakdown
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Scientists | 12 | 31% |
Practitioners (doctors, other healthcare professionals) | 4 | 10% |
Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
Geographical breakdown
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United Kingdom | 11 | 1% |
India | 4 | <1% |
Australia | 4 | <1% |
Germany | 3 | <1% |
Netherlands | 3 | <1% |
Switzerland | 2 | <1% |
New Zealand | 2 | <1% |
Canada | 2 | <1% |
Other | 15 | 2% |
Unknown | 785 | 92% |
Demographic breakdown
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Researcher | 207 | 24% |
Student > Ph. D. Student | 135 | 16% |
Student > Master | 103 | 12% |
Other | 68 | 8% |
Professor > Associate Professor | 53 | 6% |
Other | 195 | 23% |
Unknown | 92 | 11% |
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Social Sciences | 106 | 12% |
Psychology | 62 | 7% |
Nursing and Health Professions | 51 | 6% |
Agricultural and Biological Sciences | 38 | 4% |
Other | 143 | 17% |
Unknown | 142 | 17% |