| Title |
Stem cell dynamics and pretumor progression in the intestinal tract
|
|---|---|
| Published in |
Journal of Gastroenterology, April 2016
|
| DOI | 10.1007/s00535-016-1211-3 |
| Pubmed ID | |
| Authors |
Huiying Ma, Folkert H. M. Morsink, George Johan Arnold Offerhaus, Wendy W. J. de Leng |
| Abstract |
Colorectal carcinogenesis is a process that follows a stepwise cascade that goes from the normal to an invisible pretumor stage ultimately leading to grossly visible tumor progression. During pretumor progression, an increasing accumulation of genetic alterations occurs, by definition without visible manifestations. It is generally thought that stem cells in the crypt base are responsible for this initiation of colorectal cancer progression because they are the origin of the differentiated epithelial cells that occupy the crypt. Furthermore, they are characterized by a long life span that enables them to acquire these cumulative mutations. Recent studies visualized the dynamics of stem cells both in vitro and in vivo. Translating this work into clinical applications will contribute to the evaluation of patients' predisposition for colorectal carcinogenesis and may help in the design of preventive measures for high-risk groups. In this review, we outline the progress made in the research into tracing stem cell dynamics. Further, we highlight the importance and potential clinical value of tracing stem cell dynamics in pretumor progression. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 26% |
| Researcher | 4 | 11% |
| Student > Bachelor | 4 | 11% |
| Student > Doctoral Student | 3 | 9% |
| Lecturer | 2 | 6% |
| Other | 6 | 17% |
| Unknown | 7 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 23% |
| Agricultural and Biological Sciences | 8 | 23% |
| Medicine and Dentistry | 6 | 17% |
| Materials Science | 2 | 6% |
| Immunology and Microbiology | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 6 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2016.
All research outputs
#20,323,943
of 22,867,327 outputs
Outputs from Journal of Gastroenterology
#926
of 1,090 outputs
Outputs of similar age
#253,439
of 299,158 outputs
Outputs of similar age from Journal of Gastroenterology
#15
of 17 outputs
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