| Title |
Interaction Between Odor Identification Deficit and APOE4 Predicts 6-Year Cognitive Decline in Elderly Individuals
|
|---|---|
| Published in |
Behavior Genetics, November 2019
|
| DOI | 10.1007/s10519-019-09980-9 |
| Pubmed ID | |
| Authors |
Jonas K. Olofsson, Maria Larsson, Catalina Roa, Donald A. Wilson, Erika Jonsson Laukka |
| Abstract |
Olfactory identification impairment might indicate future cognitive decline in elderly individuals. An unresolved question is to what extent this effect is dependent on the ApoE-ε4, a genotype associated with risk of Alzheimer's Disease (AD). Given the current concern about reproducibility in empirical research, we assessed this issue in a large sample (n = 1637) of older adults (60 - 96 years) from the population-based longitudinal Swedish National Study on Aging and Care in Kungsholmen (SNAC-K). A hierarchical regression analysis was carried out to determine if a low score on an odor identification test, and the presence of ApoE-ε4, would predict the magnitude of a prospective 6-year change in the Mini-Mental State Examination (MMSE) after controlling for demographic, health-related, and cognitive variables. We found that overall, lower odor identification performance was predictive of cognitive decline, and, as hypothesized, we found that the effect was most pronounced among ApoE-ε4 carriers. Our results from this high-powered sample suggest that in elderly carriers of the ApoE-ε4 allele, odor identification impairment provides an indication of future cognitive decline, which has relevance for the prognosis of AD. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Sweden | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 1 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 56 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 14% |
| Student > Master | 7 | 13% |
| Researcher | 7 | 13% |
| Student > Postgraduate | 3 | 5% |
| Student > Ph. D. Student | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 27 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 10 | 18% |
| Neuroscience | 8 | 14% |
| Medicine and Dentistry | 6 | 11% |
| Nursing and Health Professions | 2 | 4% |
| Social Sciences | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 28 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2019.
All research outputs
#2,707,323
of 23,177,498 outputs
Outputs from Behavior Genetics
#140
of 917 outputs
Outputs of similar age
#65,716
of 458,255 outputs
Outputs of similar age from Behavior Genetics
#7
of 18 outputs
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So far Altmetric has tracked 917 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one has done well, scoring higher than 84% of its peers.
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.