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Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, May 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Citations

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232 Dimensions

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290 Mendeley
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1 CiteULike
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Title
Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain
Published in
Proceedings of the National Academy of Sciences of the United States of America, May 2016
DOI 10.1073/pnas.1605245113
Pubmed ID
Authors

Wen Li, Elisabet Englund, Håkan Widner, Bengt Mattsson, Danielle van Westen, Jimmy Lätt, Stig Rehncrona, Patrik Brundin, Anders Björklund, Olle Lindvall, Jia-Yi Li

Abstract

Clinical trials using cells derived from embryonic ventral mesencephalon have shown that transplanted dopaminergic neurons can survive and function in the long term, as demonstrated by in vivo brain imaging using (18)F-fluorodopa and (11)C-raclopride positron emission tomography. Here we report the postmortem analysis of a patient with Parkinson's disease who 24 y earlier underwent unilateral transplantation of embryonic dopaminergic neurons in the putamen and subsequently exhibited major motor improvement and recovery of striatal dopaminergic function. Histopathological analysis showed that a dense, near-normal graft-derived dopaminergic reinnervation of the putamen can be maintained for a quarter of a century despite severe host brain pathology and with no evidence of immune response. In addition, ubiquitin- and α-synuclein-positive inclusions were seen, some with the appearance of typical Lewy bodies, in 11-12% of the grafted dopaminergic neurons, reflecting the spread of pathology from the host brain to the transplants. Because the clinical benefits induced by transplantation in this patient were gradually lost after 14 y posttransplantation, our findings provide the first reported evidence, to our knowledge, that even a viable dopaminergic graft giving rise to extensive striatal reinnervation may lose its efficacy if widespread degenerative changes develop in the host brain.

X Demographics

X Demographics

The data shown below were collected from the profiles of 29 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 290 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
United Kingdom 2 <1%
Portugal 1 <1%
Finland 1 <1%
France 1 <1%
Japan 1 <1%
Ireland 1 <1%
Unknown 280 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 47 16%
Student > Ph. D. Student 44 15%
Researcher 40 14%
Student > Master 31 11%
Other 18 6%
Other 45 16%
Unknown 65 22%
Readers by discipline Count As %
Neuroscience 65 22%
Biochemistry, Genetics and Molecular Biology 45 16%
Agricultural and Biological Sciences 43 15%
Medicine and Dentistry 26 9%
Chemistry 8 3%
Other 30 10%
Unknown 73 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 125. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2018.
All research outputs
#331,243
of 25,307,332 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#6,027
of 102,717 outputs
Outputs of similar age
#5,976
of 305,055 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#139
of 842 outputs
Altmetric has tracked 25,307,332 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 102,717 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,055 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 842 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.