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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Inherited Variants in SULT1E1 and Response to Abiraterone Acetate by Men with Metastatic Castration Refractory Prostate Cancer
|
|---|---|
| Published in |
The Journal of Urology, May 2016
|
| DOI | 10.1016/j.juro.2016.04.079 |
| Pubmed ID | |
| Authors |
Neeraj Agarwal, Anitha B. Alex, James M. Farnham, Shiven Patel, David Gill, Tyler H. Buckley, Robert A. Stephenson, Lisa Cannon-Albright |
| Abstract |
Germline variations in genes involved in androgen biosynthesis and metabolic pathways may predict response to abiraterone acetate (AA) in men with metastatic castration refractory prostate cancer (mCRPC), and serve as prognostic and predictive biomarkers to allow more individualized therapy. 832 single nucleotide polymorphisms (SNPs) from the Illumina OmniExpress genotyping platform within the boundaries of 61 candidate genes reported to be involved in the androgen metabolic pathway were investigated for association with time to treatment failure (TTF) in 68 Caucasian men with mCRPC undergoing treatment with AA. Cox-proportional hazard analysis was employed using Gleason score (GS), age, level of alkaline phosphatase, and PSA at treatment initiation as covariates and assessing each SNP under an allele-carriage genetic model in which carriage of one or more minor alleles contributes to increased risk. Subset analyses were employed to determine if metastasis site or prior treatment by ketoconazole or docetaxel interact with the SNPs investigated. Six SNPs in SULT1E1 were associated with TTF on AA therapy after False Discovery Rate (FDR) correction for multiple testing (q < 0.05) while controlling for GS, age, level of alkaline phosphatase, and PSA at treatment initiation. SNPs in SULT1E1 (estrogen sulfotransferase gene) were significantly associated with TTF on AA therapy, and may serve as predictive markers for treatment with AA. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 38% |
| Scientists | 3 | 38% |
| Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 18% |
| Student > Ph. D. Student | 4 | 14% |
| Student > Bachelor | 4 | 14% |
| Professor | 2 | 7% |
| Student > Postgraduate | 2 | 7% |
| Other | 6 | 21% |
| Unknown | 5 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 18% |
| Chemistry | 3 | 11% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Agricultural and Biological Sciences | 1 | 4% |
| Other | 4 | 14% |
| Unknown | 7 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2016.
All research outputs
#7,493,233
of 25,748,735 outputs
Outputs from The Journal of Urology
#17
of 114 outputs
Outputs of similar age
#98,605
of 313,261 outputs
Outputs of similar age from The Journal of Urology
#7
of 30 outputs
Altmetric has tracked 25,748,735 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 114 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,261 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.