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Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, August 2007
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 X user
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5 patents

Citations

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674 Dimensions

Readers on

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245 Mendeley
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1 CiteULike
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Title
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
Published in
Proceedings of the National Academy of Sciences of the United States of America, August 2007
DOI 10.1073/pnas.0702553104
Pubmed ID
Authors

Sung-Chun Tang, Thiruma V. Arumugam, Xiangru Xu, Aiwu Cheng, Mohamed R. Mughal, Dong Gyu Jo, Justin D. Lathia, Dominic A. Siler, Srinivasulu Chigurupati, Xin Ouyang, Tim Magnus, Simonetta Camandola, Mark P. Mattson

Abstract

The innate immune system senses the invasion of pathogenic microorganisms and tissue injury through Toll-like receptors (TLR), a mechanism thought to be limited to immune cells. We now report that neurons express several TLRs, and that the levels of TLR2 and -4 are increased in neurons in response to IFN-gamma stimulation and energy deprivation. Neurons from both TLR2 knockout and -4 mutant mice were protected against energy deprivation-induced cell death, which was associated with decreased activation of a proapoptotic signaling cascade involving jun N-terminal kinase and the transcription factor AP-1. TLR2 and -4 expression was increased in cerebral cortical neurons in response to ischemia/reperfusion injury, and the amount of brain damage and neurological deficits caused by a stroke were significantly less in mice deficient in TLR2 or -4 compared with WT control mice. Our findings establish a proapoptotic signaling pathway for TLR2 and -4 in neurons that may render them vulnerable to ischemic death.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 245 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Japan 2 <1%
Poland 1 <1%
China 1 <1%
Unknown 238 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 49 20%
Researcher 40 16%
Student > Master 38 16%
Student > Bachelor 22 9%
Student > Doctoral Student 16 7%
Other 39 16%
Unknown 41 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 62 25%
Medicine and Dentistry 40 16%
Neuroscience 39 16%
Biochemistry, Genetics and Molecular Biology 25 10%
Immunology and Microbiology 7 3%
Other 19 8%
Unknown 53 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2021.
All research outputs
#7,665,113
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#62,482
of 101,438 outputs
Outputs of similar age
#24,831
of 70,931 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#311
of 500 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,931 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 500 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.