| Title |
A Genome-Wide Association Study in isolated populations reveals new genes associated to common food likings
|
|---|---|
| Published in |
Reviews in Endocrine and Metabolic Disorders, April 2016
|
| DOI | 10.1007/s11154-016-9354-3 |
| Pubmed ID | |
| Authors |
Nicola Pirastu, Maarten Kooyman, Michela Traglia, Antonietta Robino, Sara M. Willems, Giorgio Pistis, Najaf Amin, Cinzia Sala, Lennart C. Karssen, Cornelia Van Duijn, Daniela Toniolo, Paolo Gasparini |
| Abstract |
Food preferences are the first factor driving food choice and thus nutrition. They involve numerous different senses such as taste and olfaction as well as various other factors such as personal experiences and hedonistic aspects. Although it is clear that several of these have a genetic basis, up to now studies have focused mostly on the effects of polymorphisms of taste receptor genes. Therefore, we have carried out one of the first large scale (4611 individuals) GWAS on food likings assessed for 20 specific food likings belonging to 4 different categories (vegetables, fatty, dairy and bitter). A two-step meta-analysis using three different isolated populations from Italy for the discovery step and two populations from The Netherlands and Central Asia for replication, revealed 15 independent genome-wide significant loci (p < 5 × 10(-8)) for 12 different foods. None of the identified genes coded for either taste or olfactory receptors suggesting that genetics impacts in determining food likings in a much broader way than simple differences in taste perception. These results represent a further step in uncovering the genes that underlie liking of common foods that in the end will greatly help understanding the genetics of human nutrition in general. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 2% |
| Unknown | 53 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 24% |
| Student > Bachelor | 5 | 9% |
| Student > Master | 5 | 9% |
| Student > Ph. D. Student | 5 | 9% |
| Student > Doctoral Student | 3 | 6% |
| Other | 6 | 11% |
| Unknown | 17 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 20% |
| Medicine and Dentistry | 8 | 15% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Neuroscience | 3 | 6% |
| Economics, Econometrics and Finance | 3 | 6% |
| Other | 5 | 9% |
| Unknown | 20 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2016.
All research outputs
#15,061,979
of 23,917,076 outputs
Outputs from Reviews in Endocrine and Metabolic Disorders
#334
of 505 outputs
Outputs of similar age
#163,451
of 301,768 outputs
Outputs of similar age from Reviews in Endocrine and Metabolic Disorders
#8
of 11 outputs
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