Title |
Gastroesophageal Reflux in Cystic Fibrosis: Current Understandings of Mechanisms and Management
|
---|---|
Published in |
Current Gastroenterology Reports, April 2012
|
DOI | 10.1007/s11894-012-0261-9 |
Pubmed ID | |
Authors |
Hayat M. Mousa, Frederick W. Woodley |
Abstract |
Cystic fibrosis (CF) is an inherited disease that affects both the lungs and the digestive system in children and adults. Thick mucus fills the gut and blocks lumens of the pancreas and hepatobiliary systems, creating insufficient pancreas function and liver disease. Chronic gastrointestinal (GI) complications, including intestinal obstruction, occur in neonates, and poor digestion and gastroesophageal reflux disease (GERD) in children. Although GI symptoms tend to improve with age, CF and associated GERD eventually create respiratory insufficiency; the only available treatment option at this stage is a bilateral lung transplant, which carries considerable morbidity and mortality. While GERD may reoccur as a complication of lung transplantation, GERD symptoms are often reduced following a fundoplication. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 2% |
Italy | 1 | 2% |
Unknown | 62 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 10 | 16% |
Student > Bachelor | 10 | 16% |
Student > Ph. D. Student | 7 | 11% |
Researcher | 5 | 8% |
Student > Postgraduate | 4 | 6% |
Other | 14 | 22% |
Unknown | 14 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 30 | 47% |
Agricultural and Biological Sciences | 4 | 6% |
Nursing and Health Professions | 3 | 5% |
Sports and Recreations | 3 | 5% |
Psychology | 2 | 3% |
Other | 5 | 8% |
Unknown | 17 | 27% |