HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design

Chapter 1 What Is a B Cell Epitope

Chapter 2 Molecular Design Versus Empirical Discovery in Peptide-Based Vaccines: Coming to Terms with Fuzzy Recognition Sites and Ill-Defined Structure-Function Relationships in Immunology

Chapter 3 Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopes

Chapter 4 Specificity, Polyspecificity and Heterospecificity of Antibody-Antigen Recognition

Chapter 5 Reductionism and the Search for Structure: Function Relationships in Antibody Molecules

Chapter 6 Reductionism and Complexity in Molecular Biology: Scientists Now Have the Tools to Unravel Biological Complexity and Overcome the Limitations of Reductionism

Chapter 7 Editorial: Biological Complexity Emerges from the Ashes of Genetic Reductionism

Chapter 8 The Rational Design of Biological Complexity: A Deceptive Metaphor

Chapter 9 Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking

Chapter 10 Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking

Chapter 11 Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases

Chapter 12 Limitations to the Structure-Based Design of HIV-1 Vaccine Immunogens

Chapter 13 Two Meanings of Reverse Vaccinology and the Empirical Nature of Vaccine Science

Chapter 14 Requirements for Empirical Immunogenicity Trials, Rather than Structure-Based Design, for Developing an Effective HIV Vaccine

Chapter 15 Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013

Chapter 16 Editorial: Paradigm Changes Are Required in HIV Vaccine Research

Chapter 17 An Outdated Notion of Antibody Specificity Is One of the Major Detrimental Assumptions of the Structure-Based Reverse Vaccinology Paradigm, Which Prevented It from Helping to Develop an Effective HIV-1 Vaccine

Chapter 18 More Surprises in the Development of an HIV Vaccine (General Commentary)

Chapter 19 Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 Not Inform the Rational Design of an HIV-1 Vaccine?

Chapter 20 Old and New Concepts and Strategies in HIV Vaccinology: A Report from a Workshop Held in Rome on 17 June 2016

Chapter 21 Structure-Based Reverse Vaccinology Failed in the Case of HIV Because It Disregarded Accepted Immunological Theory

Chapter 22 Immune Systems Rather than Antigenic Epitopes Elicit and Produce Protective Antibodies Against HIV

Chapter 23 Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design

Chapter 24 Viral Species, Viral Genomes and HIV Vaccine Design: Is the Rational Design of Biological Complexity a Utopia?