| Title |
Intestinal stem cell response to injury: lessons from Drosophila
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, May 2016
|
| DOI | 10.1007/s00018-016-2235-9 |
| Pubmed ID | |
| Authors |
Huaqi Jiang, Aiguo Tian, Jin Jiang |
| Abstract |
Many adult tissues and organs are maintained by resident stem cells that are activated in response to injury but the mechanisms that regulate stem cell activity during regeneration are still poorly understood. An emerging system to study such problem is the Drosophila adult midgut. Recent studies have identified both intrinsic factors and extrinsic niche signals that control the proliferation, self-renewal, and lineage differentiation of Drosophila adult intestinal stem cells (ISCs). These findings set up the stage to interrogate how niche signals are regulated and how they are integrated with cell-intrinsic factors to control ISC activity during normal homeostasis and regeneration. Here we review the current understanding of the mechanisms that control ISC self-renewal, proliferation, and lineage differentiation in Drosophila adult midgut with a focus on the niche signaling network that governs ISC activity in response to injury. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 114 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 19% |
| Researcher | 20 | 17% |
| Student > Master | 16 | 14% |
| Student > Bachelor | 16 | 14% |
| Professor > Associate Professor | 4 | 3% |
| Other | 12 | 10% |
| Unknown | 25 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 30% |
| Biochemistry, Genetics and Molecular Biology | 30 | 26% |
| Immunology and Microbiology | 6 | 5% |
| Chemistry | 4 | 3% |
| Medicine and Dentistry | 4 | 3% |
| Other | 8 | 7% |
| Unknown | 28 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2016.
All research outputs
#13,687,586
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#2,657
of 4,151 outputs
Outputs of similar age
#143,079
of 300,137 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#47
of 88 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.