| Title |
Patients with Fibromyalgia Display Less Functional Connectivity in the Brain's Pain Inhibitory Network
|
|---|---|
| Published in |
Molecular Pain, January 2012
|
| DOI | 10.1186/1744-8069-8-32 |
| Pubmed ID | |
| Authors |
Karin B Jensen, Rita Loitoile, Eva Kosek, Frank Petzke, Serena Carville, Peter Fransson, Hanke Marcus, Steven CR Williams, Ernest Choy, Yves Mainguy, Olivier Vitton, Richard H Gracely, Randy Gollub, Martin Ingvar, Jian Kong |
| Abstract |
There is evidence for augmented processing of pain and impaired endogenous pain inhibition in Fibromyalgia syndrome (FM). In order to fully understand the mechanisms involved in FM pathology, there is a need for closer investigation of endogenous pain modulation. In the present study, we compared the functional connectivity of the descending pain inhibitory network in age-matched FM patients and healthy controls (HC).We performed functional magnetic resonance imaging (fMRI) in 42 subjects; 14 healthy and 28 age-matched FM patients (2 patients per HC), during randomly presented, subjectively calibrated pressure pain stimuli. A seed-based functional connectivity analysis of brain activity was performed. The seed coordinates were based on the findings from our previous study, comparing the fMRI signal during calibrated pressure pain in FM and HC: the rostral anterior cingulate cortex (rACC) and thalamus. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 17% |
| Mexico | 1 | 17% |
| United Kingdom | 1 | 17% |
| United States | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Scientists | 1 | 17% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 312 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 2% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Sweden | 1 | <1% |
| Australia | 1 | <1% |
| Denmark | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 301 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 17% |
| Student > Master | 44 | 14% |
| Student > Bachelor | 37 | 12% |
| Researcher | 30 | 10% |
| Student > Doctoral Student | 19 | 6% |
| Other | 66 | 21% |
| Unknown | 63 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 79 | 25% |
| Neuroscience | 46 | 15% |
| Psychology | 43 | 14% |
| Agricultural and Biological Sciences | 19 | 6% |
| Nursing and Health Professions | 13 | 4% |
| Other | 40 | 13% |
| Unknown | 72 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2013.
All research outputs
#7,301,919
of 25,654,806 outputs
Outputs from Molecular Pain
#146
of 671 outputs
Outputs of similar age
#59,792
of 251,300 outputs
Outputs of similar age from Molecular Pain
#15
of 47 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 671 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,300 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.