Title |
Novel genetic risk factors for asthma in African American children: Precision Medicine and the SAGE II Study
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Published in |
Immunogenetics, May 2016
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DOI | 10.1007/s00251-016-0914-1 |
Pubmed ID | |
Authors |
Marquitta J. White, O. Risse-Adams, P. Goddard, M. G. Contreras, J. Adams, D. Hu, C. Eng, S. S. Oh, A. Davis, K. Meade, E. Brigino-Buenaventura, M. A. LeNoir, K. Bibbins-Domingo, M. Pino-Yanes, E. G. Burchard |
Abstract |
Asthma, an inflammatory disorder of the airways, is the most common chronic disease of children worldwide. There are significant racial/ethnic disparities in asthma prevalence, morbidity, and mortality among US children. This trend is mirrored in obesity, which may share genetic and environmental risk factors with asthma. The majority of asthma biomedical research has been performed in populations of European decent. We sought to identify genetic risk factors for asthma in African American children. We also assessed the generalizability of genetic variants associated with asthma in European and Asian populations to African American children. Our study population consisted of 1227 (812 asthma cases, 415 controls) African American children with genome-wide single nucleotide polymorphism (SNP) data. Logistic regression was used to identify associations between SNP genotype and asthma status. We identified a novel variant in the PTCHD3 gene that is significantly associated with asthma (rs660498, p = 2.2 × 10(-7)) independent of obesity status. Approximately 5 % of previously reported asthma genetic associations identified in European populations replicated in African Americans. Our identification of novel variants associated with asthma in African American children, coupled with our inability to replicate the majority of findings reported in European Americans, underscores the necessity for including diverse populations in biomedical studies of asthma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 57% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 76 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 13% |
Student > Bachelor | 10 | 13% |
Researcher | 9 | 12% |
Student > Master | 9 | 12% |
Student > Postgraduate | 7 | 9% |
Other | 10 | 13% |
Unknown | 21 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 19 | 25% |
Medicine and Dentistry | 9 | 12% |
Social Sciences | 5 | 7% |
Nursing and Health Professions | 4 | 5% |
Agricultural and Biological Sciences | 4 | 5% |
Other | 9 | 12% |
Unknown | 26 | 34% |