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Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

Overview of attention for article published in Science, August 1997
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

patent
65 patents

Citations

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1971 Dimensions

Readers on

mendeley
405 Mendeley
citeulike
5 CiteULike
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Title
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Published in
Science, August 1997
DOI 10.1126/science.277.5328.955
Pubmed ID
Authors

Toru M. Nakamura, Gregg B. Morin, Karen B. Chapman, Scott L. Weinrich, William H. Andrews, Joachim Lingner, Calvin B. Harley, Thomas R. Cech

Abstract

Catalytic protein subunits of telomerase from the ciliate Euplotes aediculatus and the yeast Saccharomyces cerevisiae contain reverse transcriptase motifs. Here the homologous genes from the fission yeast Schizosaccharomyces pombe and human are identified. Disruption of the S. pombe gene resulted in telomere shortening and senescence, and expression of mRNA from the human gene correlated with telomerase activity in cell lines. Sequence comparisons placed the telomerase proteins in the reverse transcriptase family but revealed hallmarks that distinguish them from retroviral and retrotransposon relatives. Thus, the proposed telomerase catalytic subunits are phylogenetically conserved and represent a deep branch in the evolution of reverse transcriptases.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 405 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 2%
United Kingdom 5 1%
Canada 3 <1%
Japan 2 <1%
India 1 <1%
Austria 1 <1%
Switzerland 1 <1%
Belarus 1 <1%
Germany 1 <1%
Other 2 <1%
Unknown 381 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 100 25%
Researcher 64 16%
Student > Master 58 14%
Student > Bachelor 35 9%
Student > Postgraduate 17 4%
Other 61 15%
Unknown 70 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 162 40%
Biochemistry, Genetics and Molecular Biology 104 26%
Medicine and Dentistry 25 6%
Chemistry 13 3%
Pharmacology, Toxicology and Pharmaceutical Science 5 1%
Other 16 4%
Unknown 80 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2020.
All research outputs
#2,470,643
of 22,867,327 outputs
Outputs from Science
#29,917
of 77,985 outputs
Outputs of similar age
#1,219
of 29,263 outputs
Outputs of similar age from Science
#42
of 249 outputs
Altmetric has tracked 22,867,327 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 77,985 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 62.3. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 29,263 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 249 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.