| Title |
Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation
|
|---|---|
| Published in |
Pharmaceutical Research, September 2003
|
| DOI | 10.1023/a:1025771421906 |
| Pubmed ID | |
| Authors |
Eva Y. Chi, Sampathkumar Krishnan, Theodore W. Randolph, John F. Carpenter |
| Abstract |
Irreversible protein aggregation is problematic in the biotechnology industry, where aggregation is encountered throughout the lifetime of a therapeutic protein, including during refolding, purification, sterilization, shipping, and storage processes. The purpose of the current review is to provide a fundamental understanding of the mechanisms by which proteins aggregate and by which varying solution conditions, such as temperature, pH, salt type, salt concentration, cosolutes, preservatives, and surfactants, affect this process. |
Mendeley readers
The data shown below were compiled from readership statistics for 1,153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | <1% |
| United Kingdom | 9 | <1% |
| Germany | 8 | <1% |
| Austria | 4 | <1% |
| India | 4 | <1% |
| Canada | 2 | <1% |
| Australia | 2 | <1% |
| Portugal | 2 | <1% |
| Netherlands | 1 | <1% |
| Other | 7 | <1% |
| Unknown | 1103 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 333 | 29% |
| Researcher | 193 | 17% |
| Student > Master | 168 | 15% |
| Student > Bachelor | 116 | 10% |
| Student > Doctoral Student | 67 | 6% |
| Other | 101 | 9% |
| Unknown | 175 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 261 | 23% |
| Chemistry | 180 | 16% |
| Biochemistry, Genetics and Molecular Biology | 121 | 10% |
| Engineering | 116 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 87 | 8% |
| Other | 170 | 15% |
| Unknown | 218 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2023.
All research outputs
#2,655,879
of 25,374,647 outputs
Outputs from Pharmaceutical Research
#117
of 2,983 outputs
Outputs of similar age
#3,388
of 53,937 outputs
Outputs of similar age from Pharmaceutical Research
#2
of 18 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,983 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 53,937 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.