| Title |
The MAP kinase cascade. Discovery of a new signal transduction pathway
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, November 1993
|
| DOI | 10.1007/bf01076771 |
| Pubmed ID | |
| Authors |
Natalie G. Ahn |
| Abstract |
Using biochemical techniques similar to those used by Krebs and Fischer in elucidating the cAMP kinase cascade, a protein kinase cascade has been found that represents a new pathway for signal transduction. This pathway is activated in almost all cells that have been examined by many different growth and differentiation factors, suggesting control of different cell responses. At this writing, four tiers of growth factor regulated kinases, each tier represented by more than one enzyme, have been reconstituted in vitro to form the MAP kinase cascade. Preliminary findings suggesting multiple feedback or feedforward regulation of several components in the cascade predict higher complexity than a simple linear pathway. |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 5% |
| Unknown | 19 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 30% |
| Lecturer | 3 | 15% |
| Professor | 3 | 15% |
| Researcher | 2 | 10% |
| Unspecified | 1 | 5% |
| Other | 3 | 15% |
| Unknown | 2 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 30% |
| Biochemistry, Genetics and Molecular Biology | 5 | 25% |
| Medicine and Dentistry | 3 | 15% |
| Immunology and Microbiology | 1 | 5% |
| Unspecified | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 2 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2016.
All research outputs
#7,480,713
of 22,867,327 outputs
Outputs from Molecular and Cellular Biochemistry
#418
of 2,308 outputs
Outputs of similar age
#6,142
of 21,560 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#2
of 13 outputs
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So far Altmetric has tracked 2,308 research outputs from this source. They receive a mean Attention Score of 3.9. This one has gotten more attention than average, scoring higher than 50% of its peers.
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