Title |
Time-varying Effects of GABRG1 and Maladaptive Peer Behavior on Externalizing Behavior from Childhood to Adulthood: Testing Gene × Environment × Development Effects
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Published in |
Journal of Youth and Adolescence, November 2019
|
DOI | 10.1007/s10964-019-01171-3 |
Pubmed ID | |
Authors |
Elisa M. Trucco, Songshan Yang, James J. Yang, Robert A. Zucker, Runze Li, Anne Buu |
Abstract |
Engagement in externalizing behavior is problematic. Deviant peer affiliation increases risk for externalizing behavior. Yet, peer effects vary across individuals and may differ across genes. This study determines gene × environment × development interactions as they apply to externalizing behavior from childhood to adulthood. A sample (n = 687; 68% male, 90% White) of youth from the Michigan Longitudinal Study was assessed from ages 10 to 25. Interactions between γ-amino butyric acid type A receptor γ1 subunit (GABRG1; rs7683876, rs13120165) and maladaptive peer behavior on externalizing behavior were examined using time-varying effect modeling. The findings indicate a sequential risk gradient in the influence of maladaptive peer behavior on externalizing behavior depending on the number of G alleles during childhood through adulthood. Individuals with the GG genotype are most vulnerable to maladaptive peer influences, which results in greater externalizing behavior during late childhood through early adulthood. |
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Scientists | 1 | 33% |
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Geographical breakdown
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Student > Doctoral Student | 2 | 11% |
Unspecified | 1 | 6% |
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Librarian | 1 | 6% |
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Medicine and Dentistry | 1 | 6% |
Other | 0 | 0% |
Unknown | 8 | 44% |