| Title |
Global variation in prevalence and incidence of amyotrophic lateral sclerosis: a systematic review and meta-analysis
|
|---|---|
| Published in |
Journal of Neurology, December 2019
|
| DOI | 10.1007/s00415-019-09652-y |
| Pubmed ID | |
| Authors |
Lu Xu, Tanxin Liu, Lili Liu, Xiaoying Yao, Lu Chen, Dongsheng Fan, Siyan Zhan, Shengfeng Wang |
| Abstract |
Amyotrophic lateral sclerosis (ALS) is a global disease, which adversely affects the life quality of patients and significantly increases the burden of families and society. We aimed to assess the changing incidence, prevalence of ALS around the world. We searched Medline, Embase, Web of Science, and Cochrane library to identify articles published until September 9, 2018. Each included study was independently reviewed for methodological quality by two reviewers. We used a random-effects model to summarize individual studies and assessed heterogeneity (I2) with the χ2 test on Cochrane's Q statistic. We identified 124 studies that were eligible for final inclusion, including 110 studies of incidence and 58 studies of prevalence. The overall crude worldwide ALS prevalence and incidence were 4.42 (95% CI 3.92-4.96) per 1,00,000 population and 1.59 (95% CI 1.39-1.81) per 1,00,000 person-years, respectively. ALS prevalence and incidence increased by age until the age of 70-79. Since 1957, incidence has been significantly rising year by year, and this upward trend was weakened after standardization. The longest survival time were in Asia (ranging from 3.74 years in South Asia to 9.23 years in West Asia). With the aggravation of population aging and the rapid growth of economy, developing regions following the development pattern of the developed regions may suffer rising ALS prevalence and incidence which may increase their disease burden as well. These data highlight the need for research into underlying mechanism and innovations in health-care systems. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 294 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 294 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 45 | 15% |
| Student > Ph. D. Student | 27 | 9% |
| Researcher | 22 | 7% |
| Student > Master | 22 | 7% |
| Student > Doctoral Student | 9 | 3% |
| Other | 29 | 10% |
| Unknown | 140 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 34 | 12% |
| Medicine and Dentistry | 25 | 9% |
| Neuroscience | 25 | 9% |
| Agricultural and Biological Sciences | 16 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 3% |
| Other | 37 | 13% |
| Unknown | 147 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 117. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2022.
All research outputs
#364,160
of 25,837,817 outputs
Outputs from Journal of Neurology
#42
of 5,075 outputs
Outputs of similar age
#8,670
of 481,837 outputs
Outputs of similar age from Journal of Neurology
#2
of 84 outputs
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We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.