| Title |
Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis
|
|---|---|
| Published in |
Breast Cancer Research, October 2005
|
| DOI | 10.1186/bcr1341 |
| Pubmed ID | |
| Authors |
Jorge S Reis-Filho, Fernanda Milanezi, Silvia Carvalho, Pete T Simpson, Dawn Steele, Kay Savage, Maryou BK Lambros, Emilio M Pereira, Jahn M Nesland, Sunil R Lakhani, Fernando C Schmitt |
| Abstract |
Metaplastic breast carcinomas constitute a heterogeneous group of neoplasms, accounting for less than 1% of all invasive mammary carcinomas. Approximately 70-80% of metaplastic breast carcinomas overexpress the epidermal growth factor receptor (EGFR). Human epidermal growth factor receptor (HER)2 and EGFR have attracted much attention in the medical literature over the past few years owing to the fact that humanized monoclonal antibodies against HER2 and therapies directed against the extracellular ligand-binding domain or the intracellular tyrosine kinase domain of EGFR have proven successful in treating certain types of human cancer. We investigated whether HER2 and EGFR overexpression was present and evaluated gene amplification in a series of metaplastic breast carcinomas. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| United States | 1 | 2% |
| Argentina | 1 | 2% |
| Unknown | 56 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 19% |
| Researcher | 10 | 17% |
| Student > Ph. D. Student | 8 | 14% |
| Student > Bachelor | 7 | 12% |
| Professor > Associate Professor | 5 | 8% |
| Other | 8 | 14% |
| Unknown | 10 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 39% |
| Agricultural and Biological Sciences | 10 | 17% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Unspecified | 1 | 2% |
| Other | 5 | 8% |
| Unknown | 9 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2020.
All research outputs
#16,721,208
of 25,373,627 outputs
Outputs from Breast Cancer Research
#1,479
of 2,052 outputs
Outputs of similar age
#66,517
of 74,893 outputs
Outputs of similar age from Breast Cancer Research
#17
of 18 outputs
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