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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol
|
|---|---|
| Published in |
Colloids & Surfaces B: Biointerfaces, March 2016
|
| DOI | 10.1016/j.colsurfb.2016.03.076 |
| Pubmed ID | |
| Authors |
Natalie Summerlin, Zhi Qu, Naisarg Pujara, Yong Sheng, Siddharth Jambhrunkar, Michael McGuckin, Amirali Popat |
| Abstract |
The naturally occurring polyphenol resveratrol (RES) has attracted increasing attention in recent years due to its antioxidant, anti-inflammatory, and anticancer activity. However, resveratrol's promising potential as a nutraceutical is hindered by its poor aqueous solubility, which limits its biological activity. Here we show that encapsulating resveratrol in colloidal mesoporous silica nanoparticles (MCM-48-RES) enhances its saturated solubility by ∼95% and increases its in vitro release kinetics compared to pure resveratrol. MCM-48-RES showed high loading capacity (20% w/w) and excellent encapsulation efficiency (100%). When tested against HT-29 and LS147T colon cancer cell lines, MCM-48-RES-mediated in vitro cell death was higher than that of pure resveratrol, mediated via the PARP and cIAP1 pathways. Finally, MCM-48-RES treatment also inhibited lipopolysaccharide-induced NF-κB activation in RAW264.7 cells, demonstrating improved anti-inflammatory activity. More broadly, our observations demonstrate the potential of colloidal mesoporous silica nanoparticles as next generation delivery carriers for hydrophobic nutraceuticals. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Unknown | 112 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 12% |
| Researcher | 13 | 12% |
| Student > Ph. D. Student | 12 | 11% |
| Student > Doctoral Student | 11 | 10% |
| Student > Bachelor | 8 | 7% |
| Other | 18 | 16% |
| Unknown | 37 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 18 | 16% |
| Chemistry | 14 | 12% |
| Agricultural and Biological Sciences | 10 | 9% |
| Materials Science | 6 | 5% |
| Medicine and Dentistry | 6 | 5% |
| Other | 13 | 12% |
| Unknown | 46 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2016.
All research outputs
#20,742,906
of 25,481,734 outputs
Outputs from Colloids & Surfaces B: Biointerfaces
#2,275
of 3,100 outputs
Outputs of similar age
#235,150
of 315,563 outputs
Outputs of similar age from Colloids & Surfaces B: Biointerfaces
#42
of 66 outputs
Altmetric has tracked 25,481,734 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,100 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,563 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.