Title |
Oncogenic viruses: Lessons learned using next-generation sequencing technologies
|
---|---|
Published in |
European Journal of Cancer (1965), May 2016
|
DOI | 10.1016/j.ejca.2016.03.086 |
Pubmed ID | |
Authors |
Ronan Flippot, Gabriel G. Malouf, Xiaoping Su, David Khayat, Jean-Philippe Spano |
Abstract |
Fifteen percent of cancers are driven by oncogenic human viruses. Four of those viruses, hepatitis B virus, human papillomavirus, Merkel cell polyomavirus, and human T-cell lymphotropic virus, integrate the host genome. Viral oncogenesis is the result of epigenetic and genetic alterations that happen during viral integration. So far, little data have been available regarding integration mechanisms and modifications in the host genome. However, the emergence of high-throughput sequencing and bioinformatic tools enables researchers to establish the landscape of genomic alterations and predict the events that follow viral integration. Cooperative working groups are currently investigating these factors in large data sets. Herein, we provide novel insights into the initiating events of cancer onset during infection with integrative viruses. Although much remains to be discovered, many improvements are expected from the clinical point of view, from better prognosis classifications to better therapeutic strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 2 | 40% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 2% |
United States | 1 | 2% |
Unknown | 57 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 20% |
Student > Master | 11 | 19% |
Student > Ph. D. Student | 9 | 15% |
Student > Bachelor | 6 | 10% |
Student > Doctoral Student | 3 | 5% |
Other | 6 | 10% |
Unknown | 12 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 20% |
Agricultural and Biological Sciences | 11 | 19% |
Medicine and Dentistry | 11 | 19% |
Immunology and Microbiology | 4 | 7% |
Nursing and Health Professions | 2 | 3% |
Other | 4 | 7% |
Unknown | 15 | 25% |