| Title |
The legacy of Drosophila imaginal discs
|
|---|---|
| Published in |
Chromosoma, May 2016
|
| DOI | 10.1007/s00412-016-0595-4 |
| Pubmed ID | |
| Authors |
Jorge V. Beira, Renato Paro |
| Abstract |
The study of Drosophila imaginal discs has contributed to a number of discoveries in developmental and cellular biology. In addition to the elucidation of the role of tissue compartments and organ-specific master regulator genes during development, imaginal discs have also become well established as models for studying cellular interactions and complex genetic pathways. Here, we review key discoveries resulting from investigations of these epithelial precursor organs, ranging from cell fate determination and transdetermination to tissue patterning. Furthermore, the design of increasingly sophisticated genetic tools over the last decades has added value to the use of imaginal discs as model systems. As a result of tissue-specific genetic screens, several components of developmentally regulated signaling pathways were identified and epistasis revealed the levels at which they function. Discs have been widely used to assess cellular interactions in their natural tissue context, contributing to a better understanding of growth regulation, tissue regeneration, and cancer. With the continuous implementation of novel tools, imaginal discs retain significant potential as model systems to address emerging questions in biology and medicine. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 33% |
| Canada | 1 | 17% |
| United States | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 83% |
| Members of the public | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 459 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Unknown | 458 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 102 | 22% |
| Student > Ph. D. Student | 88 | 19% |
| Student > Master | 50 | 11% |
| Researcher | 39 | 8% |
| Student > Doctoral Student | 22 | 5% |
| Other | 35 | 8% |
| Unknown | 123 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 199 | 43% |
| Agricultural and Biological Sciences | 82 | 18% |
| Neuroscience | 12 | 3% |
| Medicine and Dentistry | 5 | 1% |
| Computer Science | 4 | <1% |
| Other | 23 | 5% |
| Unknown | 134 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2024.
All research outputs
#4,751,793
of 25,837,817 outputs
Outputs from Chromosoma
#72
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Outputs of similar age
#67,926
of 314,582 outputs
Outputs of similar age from Chromosoma
#2
of 20 outputs
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