You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands
|
|---|---|
| Published in |
Immunity, May 2016
|
| DOI | 10.1016/j.immuni.2016.03.007 |
| Pubmed ID | |
| Authors |
Victor S. Cortez, Luisa Cervantes-Barragan, Michelle L. Robinette, Jennifer K. Bando, Yaming Wang, Theresa L. Geiger, Susan Gilfillan, Anja Fuchs, Eric Vivier, Joe C. Sun, Marina Cella, Marco Colonna |
| Abstract |
The signals guiding differentiation of innate lymphoid cells (ILCs) within tissues are not well understood. Salivary gland (SG) ILCs as well as liver and intestinal intraepithelial ILC1 have markers that denote tissue residency and transforming growth factor-β (TGF-β) imprinting. We deleted Tgfbr2 in cells expressing the ILC and NK marker NKp46 and found that SG ILCs were reduced in number. They lost distinct tissue markers, such as CD49a, and the effector molecules TRAIL and CD73. Expression of the transcription factor Eomes, which promotes NK cell differentiation, was elevated. Conversely, Eomes deletion in NKp46(+) cells enhanced TGF-β-imprinting of SG ILCs. Thus, TGF-β induces SG ILC differentiation by suppressing Eomes. TGF-β acted through a JNK-dependent, Smad4-independent pathway. Transcriptome analysis demonstrated that SG ILCs had characteristic of both NK cells and ILC1. Finally, TGF-β imprinting of SG ILCs was synchronized with SG development, highlighting the impact of tissue microenvironment on ILC development. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 17% |
| Saudi Arabia | 1 | 6% |
| Malaysia | 1 | 6% |
| Chile | 1 | 6% |
| El Salvador | 1 | 6% |
| Unknown | 11 | 61% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 67% |
| Scientists | 4 | 22% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 203 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Greece | 1 | <1% |
| Germany | 1 | <1% |
| France | 1 | <1% |
| Unknown | 199 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 21% |
| Researcher | 40 | 20% |
| Student > Bachelor | 20 | 10% |
| Student > Master | 18 | 9% |
| Student > Doctoral Student | 14 | 7% |
| Other | 21 | 10% |
| Unknown | 47 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 86 | 42% |
| Biochemistry, Genetics and Molecular Biology | 29 | 14% |
| Agricultural and Biological Sciences | 23 | 11% |
| Medicine and Dentistry | 11 | 5% |
| Business, Management and Accounting | 2 | <1% |
| Other | 9 | 4% |
| Unknown | 43 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2022.
All research outputs
#3,080,895
of 25,374,647 outputs
Outputs from Immunity
#1,949
of 4,816 outputs
Outputs of similar age
#47,033
of 312,398 outputs
Outputs of similar age from Immunity
#40
of 68 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,816 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.3. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,398 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.