| Title |
Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea
|
|---|---|
| Published in |
Diabetologia, May 2012
|
| DOI | 10.1007/s00125-012-2562-9 |
| Pubmed ID | |
| Authors |
S. Seino |
| Abstract |
Clarification of the molecular mechanisms of insulin secretion is crucial for understanding the pathogenesis and pathophysiology of diabetes and for development of novel therapeutic strategies for the disease. Insulin secretion is regulated by various intracellular signals generated by nutrients and hormonal and neural inputs. In addition, a variety of glucose-lowering drugs including sulfonylureas, glinide-derivatives, and incretin-related drugs such as dipeptidyl peptidase IV (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) receptor agonists are used for glycaemic control by targeting beta cell signalling for improved insulin secretion. There has been a remarkable increase in our understanding of the basis of beta cell signalling over the past two decades following the application of molecular biology, gene technology, electrophysiology and bioimaging to beta cell research. This review discusses cell signalling in insulin secretion, focusing on the molecular targets of ATP, cAMP and sulfonylurea, an essential metabolic signal in glucose-induced insulin secretion (GIIS), a critical signal in the potentiation of GIIS, and the commonly used glucose-lowering drug, respectively. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 192 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Switzerland | 1 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 186 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 35 | 18% |
| Researcher | 34 | 18% |
| Student > Master | 31 | 16% |
| Student > Ph. D. Student | 26 | 14% |
| Other | 10 | 5% |
| Other | 33 | 17% |
| Unknown | 23 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 53 | 28% |
| Medicine and Dentistry | 40 | 21% |
| Biochemistry, Genetics and Molecular Biology | 30 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 6% |
| Chemistry | 6 | 3% |
| Other | 22 | 11% |
| Unknown | 29 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2023.
All research outputs
#3,270,117
of 24,041,016 outputs
Outputs from Diabetologia
#1,526
of 5,207 outputs
Outputs of similar age
#20,375
of 166,451 outputs
Outputs of similar age from Diabetologia
#9
of 49 outputs
Altmetric has tracked 24,041,016 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,207 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.9. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 166,451 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.