| Title |
A novel four-dimensional analytical approach for analysis of complex samples
|
|---|---|
| Published in |
Analytical & Bioanalytical Chemistry, April 2016
|
| DOI | 10.1007/s00216-016-9460-9 |
| Pubmed ID | |
| Authors |
Susanne Stephan, Cornelia Jakob, Jörg Hippler, Oliver J. Schmitz |
| Abstract |
A two-dimensional LC (2D-LC) method, based on the work of Erni and Frei in 1978, was developed and coupled to an ion mobility-high-resolution mass spectrometer (IM-MS), which enabled the separation of complex samples in four dimensions (2D-LC, ion mobility spectrometry (IMS), and mass spectrometry (MS)). This approach works as a continuous multiheart-cutting LC system, using a long modulation time of 4 min, which allows the complete transfer of most of the first - dimension peaks to the second - dimension column without fractionation, in comparison to comprehensive two-dimensional liquid chromatography. Hence, each compound delivers only one peak in the second dimension, which simplifies the data handling even when ion mobility spectrometry as a third and mass spectrometry as a fourth dimension are introduced. The analysis of a plant extract from Ginkgo biloba shows the separation power of this four-dimensional separation method with a calculated total peak capacity of more than 8700. Furthermore, the advantage of ion mobility for characterizing unknown compounds by their collision cross section (CCS) and accurate mass in a non-target approach is shown for different matrices like plant extracts and coffee. Graphical abstract Principle of the four-dimensional separation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Canada | 1 | 1% |
| Unknown | 65 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 35% |
| Researcher | 11 | 16% |
| Student > Master | 9 | 13% |
| Student > Doctoral Student | 4 | 6% |
| Student > Bachelor | 3 | 4% |
| Other | 9 | 13% |
| Unknown | 8 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 28 | 41% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Agricultural and Biological Sciences | 3 | 4% |
| Environmental Science | 3 | 4% |
| Engineering | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 22 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2016.
All research outputs
#2,174,669
of 25,374,917 outputs
Outputs from Analytical & Bioanalytical Chemistry
#132
of 9,619 outputs
Outputs of similar age
#35,100
of 314,727 outputs
Outputs of similar age from Analytical & Bioanalytical Chemistry
#6
of 139 outputs
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So far Altmetric has tracked 9,619 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.