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Mendeley readers
Attention Score in Context
| Title |
The IGF1 pathway genes and their association with age of puberty in cattle
|
|---|---|
| Published in |
Animal Genetics, May 2012
|
| DOI | 10.1111/j.1365-2052.2012.02367.x |
| Pubmed ID | |
| Authors |
Marina R. S. Fortes, Yutao Li, Eliza Collis, Yuandan Zhang, Rachel J. Hawken |
| Abstract |
Insulin-like growth factor I (somatomedin C) (IGF1) influences gonadotrophin-releasing hormone (GnRH) neurons during puberty, and GnRH release guides pubertal development. Therefore, genes of the IGF1 pathway are biological candidates for the identification of single-nucleotide polymorphisms (SNPs) affecting age of puberty. In a genome-wide association study, genotyped heifers were Tropical Composite (TCOMP, n = 866) or Brahman (BRAH, n = 843), with observation of age at first corpus luteum defining puberty. We examined SNPs in or near genes of the IGF1 pathway and report seven genes associated with age at puberty in cattle: IGF1R, IGFBP2, IGFBP4, PERK (HUGO symbol EIF2AK3), PIK3R1, GSK3B and IRS1. SNPs in the IGF1 receptor (IGF1R) showed the most promising associations: two SNPs were associated with puberty in TCOMP (P < 0.05) and one in BRAH (P = 0.00009). This last SNP explained 2% of the genetic variation (R(2) = 2.04%) for age of puberty in BRAH. Hence, IGF1R was examined further. Additional SNPs were genotyped, and haplotypes were analysed. To test more SNPs in this gene, four new SNPs from dbSNP were selected and genotyped. Single SNP and haploytpe analysis revealed associations with age of puberty in both breeds. There were two haplotypes of 12 IGF1R SNPs associated with puberty in BRAH (P < 0.05) and one in TCOMP (P < 0.05). One haplotype of two SNPs was associated (P < 0.01) with puberty in BRAH, but not in TCOMP. In conclusion, the IGF1 pathway appeared more relevant for age of puberty in Brahman cattle, and IGF1R showed higher significance when compared with other genes from the pathway. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 2% |
| United States | 1 | 1% |
| Unknown | 79 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 17% |
| Student > Ph. D. Student | 13 | 16% |
| Student > Doctoral Student | 13 | 16% |
| Researcher | 9 | 11% |
| Student > Bachelor | 4 | 5% |
| Other | 13 | 16% |
| Unknown | 16 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 54% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Veterinary Science and Veterinary Medicine | 6 | 7% |
| Medicine and Dentistry | 4 | 5% |
| Social Sciences | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 19 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2012.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Animal Genetics
#959
of 1,314 outputs
Outputs of similar age
#138,028
of 176,271 outputs
Outputs of similar age from Animal Genetics
#10
of 15 outputs
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So far Altmetric has tracked 1,314 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
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