Title |
Mechanisms underlying celiac disease and its neurologic manifestations
|
---|---|
Published in |
Cellular and Molecular Life Sciences, April 2005
|
DOI | 10.1007/s00018-004-4109-9 |
Pubmed ID | |
Authors |
P. H. R. Green, A. Alaedini, H. W. Sander, T. H. Brannagan, N. Latov, R. L. Chin |
Abstract |
The extra-intestinal manifestations of celiac disease (CD), including ataxia and peripheral neuropathy, are increasingly being recognized as the presenting symptoms of this autoimmune disease. Although there is a greater understanding of the pathogenesis of the intestinal lesions in CD the mechanisms behind the neurologic manifestations of CD have not been elucidated. In this article, the authors review the cellular and molecular mechanisms behind the histopathologic changes in the intestine, discuss the presentation and characteristics of neurologic manifestations of CD, review the data on the mechanisms behind these manifestations, and discuss the diagnosis and treatment of CD. Molecular mimicry and intermolecular help may play a role in the development of neurologic complications. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
United States | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 63 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 23% |
Student > Bachelor | 14 | 21% |
Student > Master | 7 | 11% |
Student > Postgraduate | 5 | 8% |
Professor > Associate Professor | 5 | 8% |
Other | 11 | 17% |
Unknown | 9 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 41% |
Agricultural and Biological Sciences | 12 | 18% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Nursing and Health Professions | 4 | 6% |
Neuroscience | 2 | 3% |
Other | 4 | 6% |
Unknown | 12 | 18% |