Title |
Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study
|
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Published in |
Journal of Autism and Developmental Disorders, May 2012
|
DOI | 10.1007/s10803-012-1540-x |
Pubmed ID | |
Authors |
Ousseny Zerbo, Ana-Maria Iosif, Cheryl Walker, Sally Ozonoff, Robin L. Hansen, Irva Hertz-Picciotto |
Abstract |
We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 10 | 38% |
Mexico | 1 | 4% |
Belgium | 1 | 4% |
Netherlands | 1 | 4% |
Japan | 1 | 4% |
Unknown | 12 | 46% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 16 | 62% |
Scientists | 6 | 23% |
Science communicators (journalists, bloggers, editors) | 2 | 8% |
Practitioners (doctors, other healthcare professionals) | 2 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 1% |
Italy | 1 | <1% |
Hong Kong | 1 | <1% |
Israel | 1 | <1% |
Brazil | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 322 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 60 | 18% |
Student > Ph. D. Student | 45 | 14% |
Student > Bachelor | 42 | 13% |
Researcher | 38 | 11% |
Student > Doctoral Student | 29 | 9% |
Other | 55 | 17% |
Unknown | 63 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 71 | 21% |
Psychology | 54 | 16% |
Neuroscience | 34 | 10% |
Agricultural and Biological Sciences | 24 | 7% |
Biochemistry, Genetics and Molecular Biology | 23 | 7% |
Other | 53 | 16% |
Unknown | 73 | 22% |