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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The p150Glued CAP-Gly Domain Regulates Initiation of Retrograde Transport at Synaptic Termini
|
|---|---|
| Published in |
Neuron, April 2012
|
| DOI | 10.1016/j.neuron.2012.02.026 |
| Pubmed ID | |
| Authors |
Thomas E. Lloyd, James Machamer, Kathleen O'Hara, Ji Han Kim, Sarah E. Collins, Man Y. Wong, Brooke Sahin, Wendy Imlach, Yunpeng Yang, Edwin S. Levitan, Brian D. McCabe, Alex L. Kolodkin |
| Abstract |
p150(Glued) is the major subunit of dynactin, a complex that functions with dynein in minus-end-directed microtubule transport. Mutations within the p150(Glued) CAP-Gly microtubule-binding domain cause neurodegenerative diseases through an unclear mechanism. A p150(Glued) motor neuron degenerative disease-associated mutation introduced into the Drosophila Glued locus generates a partial loss-of-function allele (Gl(G38S)) with impaired neurotransmitter release and adult-onset locomotor dysfunction. Disruption of the p150(Glued) CAP-Gly domain in neurons causes a specific disruption of vesicle trafficking at terminal boutons (TBs), the distal-most ends of synapses. Gl(G38S) larvae accumulate endosomes along with dynein and kinesin motor proteins within swollen TBs, and genetic analyses show that kinesin and p150(Glued) function cooperatively at TBs to coordinate transport. Therefore, the p150(Glued) CAP-Gly domain regulates dynein-mediated retrograde transport at synaptic termini, and this function of dynactin is disrupted by a mutation that causes motor neuron disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 2% |
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| Israel | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 115 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 25% |
| Researcher | 30 | 24% |
| Student > Master | 15 | 12% |
| Student > Bachelor | 7 | 6% |
| Student > Doctoral Student | 6 | 5% |
| Other | 16 | 13% |
| Unknown | 18 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 48 | 39% |
| Neuroscience | 24 | 20% |
| Biochemistry, Genetics and Molecular Biology | 18 | 15% |
| Medicine and Dentistry | 6 | 5% |
| Nursing and Health Professions | 2 | 2% |
| Other | 6 | 5% |
| Unknown | 19 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2012.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Neuron
#9,172
of 9,545 outputs
Outputs of similar age
#135,136
of 173,050 outputs
Outputs of similar age from Neuron
#86
of 97 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,545 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,050 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.