Title |
Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour
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Published in |
Psychopharmacology, July 2011
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DOI | 10.1007/s00213-011-2415-0 |
Pubmed ID | |
Authors |
Serena Deiana, Akihito Watanabe, Yuki Yamasaki, Naoki Amada, Marlene Arthur, Shona Fleming, Hilary Woodcock, Patricia Dorward, Barbara Pigliacampo, Steve Close, Bettina Platt, Gernot Riedel |
Abstract |
Phytocannabinoids are useful therapeutics for multiple applications including treatments of constipation, malaria, rheumatism, alleviation of intraocular pressure, emesis, anxiety and some neurological and neurodegenerative disorders. Consistent with these medicinal properties, extracted cannabinoids have recently gained much interest in research, and some are currently in advanced stages of clinical testing. Other constituents of Cannabis sativa, the hemp plant, however, remain relatively unexplored in vivo. These include cannabidiol (CBD), cannabidivarine (CBDV), Δ(9)-tetrahydrocannabivarin (Δ(9)-THCV) and cannabigerol (CBG). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 25% |
United Kingdom | 1 | 13% |
Pakistan | 1 | 13% |
Netherlands | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | <1% |
United States | 2 | <1% |
Pakistan | 1 | <1% |
France | 1 | <1% |
Unknown | 500 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 87 | 17% |
Researcher | 78 | 15% |
Student > Master | 74 | 15% |
Student > Bachelor | 65 | 13% |
Student > Doctoral Student | 25 | 5% |
Other | 73 | 14% |
Unknown | 104 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 75 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 73 | 14% |
Neuroscience | 54 | 11% |
Biochemistry, Genetics and Molecular Biology | 41 | 8% |
Medicine and Dentistry | 38 | 8% |
Other | 99 | 20% |
Unknown | 126 | 25% |