| Title |
Therapeutic Drug Monitoring of Posaconazole: an Update
|
|---|---|
| Published in |
Current Fungal Infection Reports, May 2016
|
| DOI | 10.1007/s12281-016-0255-4 |
| Pubmed ID | |
| Authors |
Bart G. J. Dekkers, Martijn Bakker, Kim C. M. van der Elst, Marieke G. G. Sturkenboom, Anette Veringa, Lambert F. R. Span, Jan-Willem C. Alffenaar |
| Abstract |
Posaconazole is a second-generation triazole agent with a potent and broad antifungal activity. In addition to the oral suspension, a delayed-release tablet and intravenous formulation with improved pharmacokinetic properties have been introduced recently. Due to the large interindividual and intraindividual variation in bioavailability and drug-drug interactions, therapeutic drug monitoring (TDM) is advised to ensure adequate exposure and improve clinical response for posaconazole. Here, we highlight and discuss the most recent findings on pharmacokinetics and pharmacodynamics of posaconazole in the setting of prophylaxis and treatment of fungal infections and refer to the challenges associated with TDM of posaconazole. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 134 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 16% |
| Other | 13 | 10% |
| Student > Ph. D. Student | 13 | 10% |
| Student > Bachelor | 10 | 7% |
| Student > Postgraduate | 8 | 6% |
| Other | 30 | 22% |
| Unknown | 39 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 37 | 28% |
| Pharmacology, Toxicology and Pharmaceutical Science | 25 | 19% |
| Agricultural and Biological Sciences | 9 | 7% |
| Immunology and Microbiology | 5 | 4% |
| Biochemistry, Genetics and Molecular Biology | 3 | 2% |
| Other | 11 | 8% |
| Unknown | 44 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2016.
All research outputs
#18,964,511
of 23,507,405 outputs
Outputs from Current Fungal Infection Reports
#111
of 163 outputs
Outputs of similar age
#220,820
of 300,485 outputs
Outputs of similar age from Current Fungal Infection Reports
#4
of 4 outputs
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So far Altmetric has tracked 163 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
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