Title |
Escitalopram versus citalopram: the surprising role of the R-enantiomer
|
---|---|
Published in |
Psychopharmacology, May 2004
|
DOI | 10.1007/s00213-004-1865-z |
Pubmed ID | |
Authors |
Connie Sánchez, Klaus P. Bøgesø, Bjarke Ebert, Elin Heldbo Reines, Claus Braestrup |
Abstract |
Citalopram is a racemate consisting of a 1:1 mixture of the R(-)- and S(+)-enantiomers. Non-clinical studies show that the serotonin reuptake inhibitory activity of citalopram is attributable to the S-enantiomer, escitalopram. A series of recent non-clinical and clinical studies comparing escitalopram and citalopram to placebo found that equivalent doses of these two drugs, i.e. containing the same amount of the S-enantiomer, showed better effect for escitalopram. These results suggested that the R-citalopram in citalopram inhibits the effect of the S-enantiomer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 3 | 2% |
United States | 3 | 2% |
Mexico | 2 | 1% |
South Africa | 1 | <1% |
Poland | 1 | <1% |
Unknown | 139 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 25 | 17% |
Student > Ph. D. Student | 23 | 15% |
Student > Master | 22 | 15% |
Researcher | 16 | 11% |
Professor > Associate Professor | 10 | 7% |
Other | 28 | 19% |
Unknown | 25 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 18% |
Agricultural and Biological Sciences | 23 | 15% |
Chemistry | 21 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 7% |
Psychology | 8 | 5% |
Other | 25 | 17% |
Unknown | 34 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2017.
All research outputs
#2,668,983
of 22,664,644 outputs
Outputs from Psychopharmacology
#665
of 5,329 outputs
Outputs of similar age
#4,387
of 57,859 outputs
Outputs of similar age from Psychopharmacology
#8
of 23 outputs
Altmetric has tracked 22,664,644 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,329 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 57,859 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.