| Title |
The German Thorotrast Cohort Study: a review and how to get access to the data
|
|---|---|
| Published in |
Radiation and Environmental Biophysics, May 2016
|
| DOI | 10.1007/s00411-016-0651-8 |
| Pubmed ID | |
| Authors |
B. Grosche, M. Birschwilks, H. Wesch, A. Kaul, G. van Kaick |
| Abstract |
It is well known that exposures like those from (226)Ra, (224)Ra and Thorotrast(®) injections increase the risk of neoplasia in bone marrow and liver. The thorium-based radioactive contrast agent Thorotrast(®) was introduced in 1929 and applied worldwide until the 1950s, especially in angiography and arteriography. Due to the extremely long half-life of several hundred years and the life-long retention of the thorium dioxide particles in the human body, patients suffer lifetime internal exposure. The health effects from the incorporated thorium were investigated in a few cohort studies with a German study being the largest among them. This retrospective cohort study was set up in 1968 with a follow-up until 2004. The study comprises 2326 Thorotrast patients and 1890 patients of a matched control group. For those being alive at the start of the study in 1968 follow-up was done by clinical examinations on a biannual basis. For the others, causes of death were collected in various ways. Additionally, clinical, radiological and biophysical studies of patients were conducted and large efforts were made to best estimate the radiation doses associated with incorporation of the Thorotrast. The aim of this paper is to describe the cohort, important results and some open questions. The data from the German Thorotrast Study are available to other interested researchers. Information can be found at http://storedb.org . |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 1 | 14% |
| Student > Doctoral Student | 1 | 14% |
| Professor | 1 | 14% |
| Student > Master | 1 | 14% |
| Researcher | 1 | 14% |
| Other | 1 | 14% |
| Unknown | 1 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 1 | 14% |
| Agricultural and Biological Sciences | 1 | 14% |
| Physics and Astronomy | 1 | 14% |
| Medicine and Dentistry | 1 | 14% |
| Chemistry | 1 | 14% |
| Other | 0 | 0% |
| Unknown | 2 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2018.
All research outputs
#7,155,520
of 23,815,455 outputs
Outputs from Radiation and Environmental Biophysics
#111
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Outputs of similar age
#97,402
of 300,472 outputs
Outputs of similar age from Radiation and Environmental Biophysics
#2
of 5 outputs
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So far Altmetric has tracked 456 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 75% of its peers.
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