| Title |
WNT-5A: signaling and functions in health and disease
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2015
|
| DOI | 10.1007/s00018-015-2076-y |
| Pubmed ID | |
| Authors |
Kuldeep Kumawat, Reinoud Gosens |
| Abstract |
WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present extensive structural malformations. WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can also activate β-catenin signaling to relay its diverse cellular effects such as cell polarity, migration, proliferation, cell survival, and immunomodulation. Moreover, aberrant WNT-5A signaling is associated with several human pathologies such as cancer, fibrosis, and inflammation. Thus, owing to its diverse functions, WNT-5A is a crucial signaling molecule currently under intense investigation with efforts to not only delineate its signaling mechanisms and functions in physiological and pathological conditions, but also to develop strategies for its therapeutic targeting. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Unknown | 158 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 19% |
| Student > Bachelor | 25 | 16% |
| Researcher | 18 | 11% |
| Student > Master | 16 | 10% |
| Student > Doctoral Student | 8 | 5% |
| Other | 23 | 14% |
| Unknown | 38 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 47 | 30% |
| Medicine and Dentistry | 18 | 11% |
| Agricultural and Biological Sciences | 13 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 6% |
| Immunology and Microbiology | 8 | 5% |
| Other | 21 | 13% |
| Unknown | 43 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2023.
All research outputs
#7,795,073
of 24,205,409 outputs
Outputs from Cellular and Molecular Life Sciences
#1,938
of 5,581 outputs
Outputs of similar age
#94,802
of 289,624 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#21
of 55 outputs
Altmetric has tracked 24,205,409 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 5,581 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,624 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.