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Mendeley readers
Attention Score in Context
| Title |
Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity
|
|---|---|
| Published in |
Oncogene, June 2015
|
| DOI | 10.1038/onc.2015.180 |
| Pubmed ID | |
| Authors |
L O'Leary, A M van der Sloot, C R Reis, S Deegan, A E Ryan, S P S Dhami, L S Murillo, R H Cool, P Correa de Sampaio, K Thompson, G Murphy, W J Quax, L Serrano, A Samali, E Szegezdi |
| Abstract |
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a death ligand cytokine known for its cytotoxic activity against malignantly transformed cells. TRAIL induces cell death through binding to death receptors DR4 and DR5. The inhibitory decoy receptors (DcR1 and DcR2) co-expressed with death receptor 4 (DR4)/DR5 on the same cell can block the transmission of the apoptotic signal. Here, we show that DcRs also regulate TRAIL sensitivity at a supracellular level and thus represent a mechanism by which the microenvironment can diminish tumour TRAIL sensitivity. Mathematical modelling and layered or spheroid stroma-extracellular matrix-tumour cultures were used to model the tumour microenvironment. By engineering TRAIL to escape binding by DcRs, we found that DcRs do not only act in a cell-autonomous or cis-regulatory manner, but also exert trans-cellular regulation originating from stromal cells and affect tumour cells, highlighting the potent inhibitory effect of DcRs in the tumour tissue and the necessity of selective targeting of the two death-inducing TRAIL receptors to maximise efficacy.Oncogene advance online publication, 8 June 2015; doi:10.1038/onc.2015.180. |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 77 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 28% |
| Student > Bachelor | 10 | 13% |
| Student > Master | 7 | 9% |
| Researcher | 5 | 6% |
| Student > Doctoral Student | 4 | 5% |
| Other | 13 | 16% |
| Unknown | 18 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 22 | 28% |
| Agricultural and Biological Sciences | 16 | 20% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
| Medicine and Dentistry | 6 | 8% |
| Chemistry | 2 | 3% |
| Other | 7 | 9% |
| Unknown | 20 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2021.
All research outputs
#7,481,383
of 22,869,263 outputs
Outputs from Oncogene
#4,354
of 10,652 outputs
Outputs of similar age
#90,395
of 266,074 outputs
Outputs of similar age from Oncogene
#44
of 116 outputs
Altmetric has tracked 22,869,263 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,652 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,074 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.