| Title |
Over-expression of Zip-13 mRNA in kidney and lung during dietary zinc deficiency in Wistar rats
|
|---|---|
| Published in |
Molecular Biology Reports, September 2010
|
| DOI | 10.1007/s11033-010-0304-y |
| Pubmed ID | |
| Authors |
Lu Guo, Xiaoyan Hu, Tongfu Xu, Xin Qi, Yang Wan, Xiaopeng Liu, Yali Jiang, Lianying Zhang |
| Abstract |
Zinc is an essential nutrient for all organisms, which is involved in the function of numerous key enzymes in metabolism. Two gene families have been identified involved in zinc homeostasis. ZnT transporters reduce intracellular zinc while Zip transporters increase intracellular zinc. Previous studies in our laboratory have shown that Zip-1, ZnT-1, Zip-2 and LIV-1 mRNA are associated with zinc level in established human breast cancer in nude mice model. In this study, six zinc transporters: ZnT-1, ZnT-2, ZnT-4, Zip-1, Zip-8 and Zip-13 were chosen. We aim to determine the relation between zinc transporters and zinc level in kidney and lung of Wistar rats. Eighteen Wistar rats were randomly divided into three groups: normal group, zinc-deficiency group and pair-fed group. After 22 days, the rats were killed and organs samples were taken, then zinc transporters mRNA were detected by RT-PCR. Compared with the normal group, Zip-13 shows an up-regulation (P < 0.05) in zinc-deficiency group both in kidney and lung, and Zip-8 was significantly lower (P < 0.05) in zinc-deficiency group in kidney. |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 6% |
| Unknown | 17 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 17% |
| Researcher | 3 | 17% |
| Student > Bachelor | 2 | 11% |
| Student > Master | 2 | 11% |
| Lecturer | 1 | 6% |
| Other | 3 | 17% |
| Unknown | 4 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 22% |
| Neuroscience | 3 | 17% |
| Agricultural and Biological Sciences | 3 | 17% |
| Veterinary Science and Veterinary Medicine | 1 | 6% |
| Arts and Humanities | 1 | 6% |
| Other | 2 | 11% |
| Unknown | 4 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2012.
All research outputs
#20,157,329
of 22,665,794 outputs
Outputs from Molecular Biology Reports
#2,017
of 2,874 outputs
Outputs of similar age
#91,773
of 96,795 outputs
Outputs of similar age from Molecular Biology Reports
#14
of 18 outputs
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